New Sequence Variants Associated with Bone Mineral Density

Overview

Journal Nat Genet

Specialty Genetics

Date 2008 Dec 17

PMID 19079262

Citations 167

Authors

Unnur Styrkarsdottir

Bjarni V Halldorsson

Solveig Gretarsdottir

Daniel F Gudbjartsson

G Bragi Walters

Thorvaldur Ingvarsson

Thorbjorg Jonsdottir

Jona Saemundsdottir

Steinunn Snorradottir

Jacqueline R Center

Tuan V Nguyen

Peter Alexandersen

Jeffrey R Gulcher

John A Eisman

Claus Christiansen

Gunnar Sigurdsson

Augustine Kong

Unnur Thorsteinsdottir

Kari Stefansson

Affiliations

Soon will be listed here.

Abstract

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

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