The Biology of Hodgkin's Lymphoma

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2008 Dec 17

PMID 19078975

Citations 257

Authors

Ralf Kuppers

Affiliations

Soon will be listed here.

Abstract

Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however, remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the pathognomonic Hodgkin and Reed-Sternberg (HRS) cells been revealed, along with several recurrent genetic lesions. The pathogenetic role for Epstein-Barr virus infection has also been substantiated. HRS cells in classical Hodgkin's lymphoma have several characteristics that are unusual for lymphoid tumour cells, and the Hodgkin's lymphoma microenvironment is dominated by an extensive mixed, potentially inflammatory cellular infiltrate. Understanding the contribution of all of these changes to the pathogenesis of this disease is essential for the development of novel therapies.

Citing Articles

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B Cell Differentiation and the Origin and Pathogenesis of Human B Cell Lymphomas.

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Proteomic Profiling of Lymph Nodes Differentiates Classic Hodgkin Lymphoma With and Without Skeletal Involvement.

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Deciphering the Genetic Complexity of Classical Hodgkin Lymphoma: Insights and Effective Strategies.

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