Germline Polymorphism of Cancer Susceptibility Genes in Gynecologic Cancer

Overview

Journal Hum Cell

Publisher Springer

Specialty Cell Biology

Date 2008 Dec 11

PMID 19067761

Citations 11

Authors

Masatsugu Ueda

Eisaku Toji

Osamu Nunobiki

Shinji Izuma

Yoshiaki Okamoto

Kiyo Torii

Sadamu Noda

Affiliations

Soon will be listed here.

Abstract

The multifactorial process of carcinogenesis involves mutations in oncogenes, or tumor suppressor genes, as well as the influence of environmental etiological factors. Common DNA polymorphisms in low penetrance genes have emerged as genetic factors that seem to modulate an individual's susceptibility to malignancy. Genetic studies, which lead to a true association, are expected to increase understanding of the pathogenesis of each malignancy and to be a powerful tool for prevention and prognosis in the future. Here, we review the findings of genetic association studies of gene polymorphisms in gynecologic cancer with special reference to glutathione-S-transferase, FAS/CD95 and p53 genes including our recent research results.

Citing Articles

Individual effects of and polymorphisms on cervical or ovarian cancer risk: An updated meta-analysis.

Ye J, Mu Y, Wang J, He X Front Genet. 2023; 13:1074570.

PMID: 36712849 PMC: 9879013. DOI: 10.3389/fgene.2022.1074570.

Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis.

Nunobiki O, Sano D, Hata S, Ogasawara T, Ueda M Hum Cell. 2018; 31(2):149-153.

PMID: 29362984 DOI: 10.1007/s13577-018-0200-7.

XRCC1 and OGG1 Gene Polymorphisms and Breast Cancer: A Systematic Review of Literature.

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Potential impact of (rs 4645878) BAX promoter -248G>A and (rs 1042522) TP53 72Arg>pro polymorphisms on epithelial ovarian cancer patients.

Dholariya S, Mir R, Zuberi M, Yadav P, Gandhi G, Khurana N Clin Transl Oncol. 2015; 18(1):73-81.

PMID: 26209050 DOI: 10.1007/s12094-015-1338-3.

GSTM1, GSTT1, and NQO1 polymorphisms in cervical carcinogenesis.

Nunobiki O, Ueda M, Akise H, Izuma S, Torii K, Okamoto Y Hum Cell. 2015; 28(3):109-13.

PMID: 25697264 DOI: 10.1007/s13577-015-0111-9.

References

Tew K . Glutathione-associated enzymes in anticancer drug resistance. Cancer Res. 1994; 54(16):4313-20. View

Rosenthal A, Ryan A, Storey A, Harwood C, Jacobs I . p53 codon 72 polymorphism and risk of cervical cancer in UK. Lancet. 1998; 352(9131):871-2. DOI: 10.1016/S0140-6736(98)07357-7. View

Pegoraro R, Moodley M, Rom L, Chetty R, Moodley J . P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans. Int J Gynecol Cancer. 2003; 13(4):444-9. DOI: 10.1046/j.1525-1438.2003.13333.x. View

Rebbeck T . Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 1997; 6(9):733-43. View

Wiencke J, Kelsey K, Lamela R, Toscano Jr W . Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage. Cancer Res. 1990; 50(5):1585-90. View

Zehbe I, Voglino G, Wilander E, Genta F, Tommasino M . Codon 72 polymorphism of p53 and its association with cervical cancer. Lancet. 1999; 354(9174):218-9. DOI: 10.1016/S0140-6736(99)01914-5. View

Cheng L, Sturgis E, Eicher S, Char D, Spitz M, Wei Q . Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck. Int J Cancer. 1999; 84(3):220-4. DOI: 10.1002/(sici)1097-0215(19990621)84:3<220::aid-ijc4>3.0.co;2-s. View

Woods D, Vousden K . Regulation of p53 function. Exp Cell Res. 2001; 264(1):56-66. DOI: 10.1006/excr.2000.5141. View

Ueda M, Hung Y, Terai Y, Saito J, Nunobiki O, Noda S . Glutathione-S-transferase and p53 polymorphisms in cervical carcinogenesis. Gynecol Oncol. 2005; 96(3):736-40. DOI: 10.1016/j.ygyno.2004.11.005. View

10.

Contreras D, Krammer P, Potkul R, Bu P, Rossi J, Kaufmann A . Cervical cancer cells induce apoptosis of cytotoxic T lymphocytes. J Immunother. 2000; 23(1):67-74. DOI: 10.1097/00002371-200001000-00009. View

11.

Ambrosone C, Sweeney C, Coles B, Thompson P, McClure G, Korourian S . Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer. Cancer Res. 2001; 61(19):7130-5. View

12.

Ueda M, Terai Y, Kanda K, Kanemura M, Takehara M, Yamaguchi H . Fas gene promoter -670 polymorphism in gynecological cancer. Int J Gynecol Cancer. 2006; 16 Suppl 1:179-82. DOI: 10.1111/j.1525-1438.2006.00505.x. View

13.

Brooks L, Tidy J, Gusterson B, Hiller L, ONions J, Gasco M . Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus. Cancer Res. 2001; 60(24):6875-7. View

14.

Kim J, Lee C, Park Y, Kim K, Kim I, Sohn Y . Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma. Cancer. 2000; 88(9):2082-91. DOI: 10.1002/(sici)1097-0142(20000501)88:9<2082::aid-cncr14>3.0.co;2-d. View

15.

Hayes V, Hofstra R, Buys C, Hollema H, van der Zee A . Homozygous arginine-72 in wild type p53 and risk of cervical cancer. Lancet. 1998; 352(9142):1756. DOI: 10.1016/S0140-6736(05)79829-9. View

16.

Ojeda J, Ampuero S, Rojas P, Prado R, Allende J, Barton S . p53 codon 72 polymorphism and risk of cervical cancer. Biol Res. 2003; 36(2):279-83. DOI: 10.4067/s0716-97602003000200017. View

17.

Dulic V, Kaufmann W, Wilson S, Tlsty T, Lees E, Harper J . p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994; 76(6):1013-23. DOI: 10.1016/0092-8674(94)90379-4. View

18.

Suda T, Takahashi T, Golstein P, Nagata S . Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. 1993; 75(6):1169-78. DOI: 10.1016/0092-8674(93)90326-l. View

19.

Meyer D, Christodoulides L, Hong Tan K, Ketterer B . Isolation, properties and tissue distribution of rat glutathione transferase E. FEBS Lett. 1984; 173(2):327-30. DOI: 10.1016/0014-5793(84)80799-1. View

20.

Lanham S, Campbell I, Watt P, Gornall R . p53 polymorphism and risk of cervical cancer. Lancet. 1998; 352(9140):1631. DOI: 10.1016/S0140-6736(05)61083-5. View