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Near-infrared Fluorescent PH-sensitive Probes Via Unexpected Barbituric Acid Mediated Synthesis

Overview
Journal Org Lett
Publisher American Chemical Society
Specialties Biochemistry
Chemistry
Date 2008 Dec 9
PMID 19061361
Citations 8
Authors
Hyeran Lee
Mikhail Y Berezin
Kevin Guo
Jeff Kao
Samuel Achilefu
Affiliations
Soon will be listed here.
Abstract

Novel near-infrared pyrimidine-fused pH fluorescent probes were prepared by an unusual barbiturate-mediated debenzoindolation and subsequent heteroannulation. A plausible mechanistic pathway is proposed, and the final structures were further elucidated by 2D-NMR. All new compounds are highly fluorescent in the near-infrared region and possess excellent spectral sensitivities to environmental pH changes.

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Pyrazole-substituted near-infrared cyanine dyes exhibit pH-dependent fluorescence lifetime properties.

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