Species-specific Uptake of DNA by Gonococci is Mediated by a 10-base-pair Sequence

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1991 Jun 1

PMID 1904861

Citations 99

Authors

C Elkins

C E Thomas

H S Seifert

P F Sparling

Affiliations

Soon will be listed here.

Abstract

Piliated Neisseria gonorrhoeae are known to be transformed less readily if transforming DNA competes with DNA containing the 10-bp sequence GCCGTCTGAA. It has been postulated that the 10-bp sequence is a recognition sequence which is required for efficient DNA uptake. We show that the presence of various forms of this 10-bp sequence results in increased uptake of double-stranded DNA into a DNase-resistant state and allows genetic transformation by an otherwise nontransformable plasmid.

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