Heterotrimeric Coiled Coils with Core Residue Urea Side Chains

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2008 Nov 27

PMID 19032043

Citations 2

Authors

Maria L Diss

Alan J Kennan

Affiliations

Soon will be listed here.

Abstract

We report several coiled coil heterotrimers with varying core residue buried polar groups, all with T(m) values >43 degrees C. Introduction of new synthetic side chain structures, including some terminating in monosubstituted ureas, diversifies the pool of viable core residue candidates. A study of core charge pairings demonstrates that, unlike dimeric systems, trimeric coiled coils do not tolerate guanidine-guanidine contacts, even in the presence of a compensating carboxylate. Overall, the roster of feasible coiled coil designs is significantly expanded.

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