Study on Protecting Effects of Baicalin and Octreotide on Hepatic Injury in Rats with Severe Acute Pancreatitis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2008 Nov 26

PMID 19030211

Citations 7

Authors

Xi-Ping Zhang

Jie Zhang

Zheng Ren

Guang-hua Feng

Wei Zhu

Yang Cai

Qi-Jun Yang

Tong-Fa Ju

Qi Xie

Wen-Qin Yuan

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the protective effects and mechanisms of baicalin and octreotide on hepatic injury in rats with severe acute pancreatitis (SAP).

Methods: The SAP rat models were prepared and randomly assigned to the model control group, baicalin treated group, and octreotide treated group while other healthy rats were assigned to the sham-operated group. Rat mortality, levels of ALT, AST, liver and pancreas pathological changes in all groups were observed at 3, 6 and 12 h after operation. Tissue microarray (TMA) sections of hepatic tissue were prepared to observe expression levels of Bax, Bcl-2 protein and caspase-3, and changes of apoptotic indexes.

Results: Rat survival at 12 h, expression levels of Bax, caspase-3 protein and apoptotic indexes of liver were all significantly higher in treated groups than in model control group. While the liver and pancreas pathological scores, contents of ALT, AST, and expression levels of Bcl-2 protein were all lower in treated groups than in the model control group.

Conclusion: Both baicalin and octreotide can protect rats with SAP by decreasing the contents of ALT, AST and expression levels of Bcl-2 protein, and improving the expression levels of Bax protein, caspase-3 protein, and inducing apoptosis.

Citing Articles

Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms.

Liu W, Du J, Li Z, Zhang X, Zuo H World J Clin Cases. 2022; 9(34):10418-10429.

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Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms.

Xiang H, Zhang Q, Qi B, Tao X, Xia S, Song H Front Pharmacol. 2017; 8:216.

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The diffuse reduction in spleen density: an indicator of severe acute pancreatitis?.

Shao G, Zhou Y, Song Z, Jiang M, Wang X, Jin X Biosci Rep. 2016; 37(1).

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Continuous regional arterial infusion with fluorouracil and octreotide attenuates severe acute pancreatitis in a canine model.

Zhou M, Chen B, Sun H, Jin Y, Yang F, Zhang X PLoS One. 2012; 7(5):e37347.

PMID: 22655040 PMC: 3360032. DOI: 10.1371/journal.pone.0037347.

Research on scutellarin parenteral solution's protective effects in rats with severe acute pancreatitis and multiple organ injuries.

Hanqing C, Xiping Z, Jingmin O, Jun J, Dijiong W Inflammation. 2011; 35(3):1005-14.

PMID: 22105928 DOI: 10.1007/s10753-011-9404-7.

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