Study Progress on Mechanism of Severe Acute Pancreatitis Complicated with Hepatic Injury

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2007 Apr 21

PMID 17444596

Citations 7

Authors

Xi-Ping Zhang

Lei Wang

Jie Zhang

Affiliations

Soon will be listed here.

Abstract

Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis (SAP) in multiple organ injury is a hotspot in the surgical field. In clinical practice, the main complicated organ dysfunctions are shock, respiratory failure, renal failure, encephalopathy, with the rate of hepatic diseases being closely next to them. The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis, but also develop into hepatic failure and cause patient death. Its complicated pathogenic mechanism is an obstacle in clinical treatment. Among many pathogenic factors, the changes of vasoactive substances, participation of inflammatory mediators as well as OFR (oxygen free radical), endotoxin, etc. may play important roles in its progression.

Citing Articles

Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought.

Susak Y, Opalchuk K, Tkachenko O, Rudyk M, Skivka L World J Gastrointest Surg. 2022; 14(1):64-77.

PMID: 35126864 PMC: 8790329. DOI: 10.4240/wjgs.v14.i1.64.

Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms.

Liu W, Du J, Li Z, Zhang X, Zuo H World J Clin Cases. 2022; 9(34):10418-10429.

PMID: 35004974 PMC: 8686151. DOI: 10.12998/wjcc.v9.i34.10418.

Picroside II Improves Severe Acute Pancreatitis-Induced Hepatocellular Injury in Rats by Affecting JAK2/STAT3 Phosphorylation Signaling.

Piao X, Sui X, Liu B, Cui T, Qi Z Biomed Res Int. 2021; 2021:9945149.

PMID: 34368363 PMC: 8337114. DOI: 10.1155/2021/9945149.

Protection of Salvia miltiorrhizae to the spleen and thymus of rats with severe acute pancreatitis or obstructive jaundice.

Xiping Z, Chuyang L, Jie Z, Yuefang R, Meili M Mediators Inflamm. 2009; 2009:186136.

PMID: 20016826 PMC: 2790077. DOI: 10.1155/2009/186136.

Effect of salvia miltiorrhizae on the expressions of TLR4 protein in the liver of rats with SAP or OJ.

Zhang X, Liu D, Wu D, Zhu C, Ye J, Wang K Inflammation. 2009; 32(3):151-62.

PMID: 19370406 DOI: 10.1007/s10753-009-9114-6.

References

Scott P, Bruce C, Schofield D, Shiel N, Braganza J, McCloy R . Vitamin C status in patients with acute pancreatitis. Br J Surg. 1993; 80(6):750-4. DOI: 10.1002/bjs.1800800632. View

Windsor J, Fearon K, Ross J, Barclay G, Smyth E, Poxton I . Role of serum endotoxin and antiendotoxin core antibody levels in predicting the development of multiple organ failure in acute pancreatitis. Br J Surg. 1993; 80(8):1042-6. DOI: 10.1002/bjs.1800800840. View

Luster M, Germolec D, Yoshida T, Kayama F, Thompson M . Endotoxin-induced cytokine gene expression and excretion in the liver. Hepatology. 1994; 19(2):480-8. View

Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos J, Slavin J . Inflammatory mediators in acute pancreatitis. J Pathol. 2000; 190(2):117-25. DOI: 10.1002/(SICI)1096-9896(200002)190:2<117::AID-PATH494>3.0.CO;2-K. View

Moine P, McIntyre R, Schwartz M, Kaneko D, Shenkar R, Le Tulzo Y . NF-kappaB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome. Shock. 2000; 13(2):85-91. DOI: 10.1097/00024382-200013020-00001. View

Kingsnorth A . Platelet-activating factor. Scand J Gastroenterol Suppl. 1996; 219:28-31. DOI: 10.3109/00365529609104996. View

Maher J, Scott M, Saito J, Burton M . Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis. Hepatology. 1997; 25(3):624-30. DOI: 10.1002/hep.510250322. View

Wang H, Tan X, Chang H, GONZALEZ-CRUSSI F, Remick D, Hsueh W . Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. Biochem J. 1997; 322 ( Pt 2):603-8. PMC: 1218232. DOI: 10.1042/bj3220603. View

Schroeder R, Gu J, Kuo P . Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma. Hepatology. 1998; 27(3):711-9. DOI: 10.1002/hep.510270312. View

10.

Ogawa M . Acute pancreatitis and cytokines: "second attack" by septic complication leads to organ failure. Pancreas. 1998; 16(3):312-5. View

11.

Hirano T, Hirano K . Glucagon ameliorates pancreatic subcellular redistribution of lysosomal enzyme in rats with acute pancreatitis of closed duodenal loop. Dig Surg. 1999; 16(1):16-21. DOI: 10.1159/000018688. View

12.

Ueda T, Ho H, Anderson S, Takeyama Y . Pancreatitis-induced ascitic fluid and hepatocellular dysfunction in severe acute pancreatitis. J Surg Res. 1999; 82(2):305-11. DOI: 10.1006/jsre.1998.5539. View

13.

Reinhardt J, Cui X, Roudebush W . Immunofluorescent evidence of the platelet-activating factor receptor on human spermatozoa. Fertil Steril. 1999; 71(5):941-2. DOI: 10.1016/s0015-0282(99)00096-5. View

14.

Brivet F, Emilie D, Galanaud P . Pro- and anti-inflammatory cytokines during acute severe pancreatitis: an early and sustained response, although unpredictable of death. Parisian Study Group on Acute Pancreatitis. Crit Care Med. 1999; 27(4):749-55. DOI: 10.1097/00003246-199904000-00029. View

15.

Ji Z, Wang B, Li S . [The role of platelet activating factor in pathogenesis of acute pancreatitis in dogs]. Zhonghua Wai Ke Za Zhi. 1997; 35(2):108-10. View

16.

Mao E, Zhang S, Han T . [Pancreatic ischemia: a continuous injury factor in acute necrotic pancreatitis]. Zhonghua Wai Ke Za Zhi. 1997; 35(3):150-2. View

17.

Shields C, Sookhai S, Winter D, Dowdall J, Kingston G, Parfrey N . Attenuation of pancreatitis-induced pulmonary injury by aerosolized hypertonic saline. Surg Infect (Larchmt). 2003; 2(3):215-23; discussion 223-4. DOI: 10.1089/109629601317202696. View

18.

Ammori B . Role of the gut in the course of severe acute pancreatitis. Pancreas. 2003; 26(2):122-9. DOI: 10.1097/00006676-200303000-00006. View

19.

De Dios I, Perez M, de La Mano A, Sevillano S, Orfao A, Ramudo L . Contribution of circulating leukocytes to cytokine production in pancreatic duct obstruction-induced acute pancreatitis in rats. Cytokine. 2003; 20(6):295-303. DOI: 10.1006/cyto.2002.2011. View

20.

Yousaf M, McCallion K, Diamond T . Management of severe acute pancreatitis. Br J Surg. 2003; 90(4):407-20. DOI: 10.1002/bjs.4179. View