J-difference Lactate Editing at 3.0 Tesla in the Presence of Strong Lipids

Overview

Journal J Magn Reson Imaging

Date 2008 Nov 26

PMID 19025937

Citations 8

Authors

Mari A Smith

Jason A Koutcher

Kristen L Zakian

Affiliations

Soon will be listed here.

Abstract

Purpose: To implement in vivo detection of lactate in the presence of lipids by proton magnetic resonance spectroscopy at a 3 Tesla (T) field strength for potential applications in human tumors outside of the brain.

Materials And Methods: The BASING J-difference sequence was implemented in the presence of high lipid concentrations in phantoms and in vivo at 3 Tesla.

Results: The effectiveness of the lactate editing scheme is demonstrated in phantoms containing both lactate and lipids and in vivo in ischemic induced human muscle.

Conclusion: The ability of the BASING J-difference technique to detect lactate in the presence of strong lipid signals outside the brain at 3T is feasible. This robust technique should permit noninvasive lactate measurements in human tumors to investigate its potential as a prognostic indicator.

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References

Nordsmark M, Alsner J, Keller J, Nielsen O, JENSEN O, Horsman M . Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br J Cancer. 2001; 84(8):1070-5. PMC: 2363869. DOI: 10.1054/bjoc.2001.1728. View

Meyerspeer M, Kemp G, Mlynarik V, Krssak M, Szendroedi J, Nowotny P . Direct noninvasive quantification of lactate and high energy phosphates simultaneously in exercising human skeletal muscle by localized magnetic resonance spectroscopy. Magn Reson Med. 2007; 57(4):654-60. PMC: 4876926. DOI: 10.1002/mrm.21188. View

Quennet V, Yaromina A, Zips D, Rosner A, Walenta S, Baumann M . Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. Radiother Oncol. 2006; 81(2):130-5. DOI: 10.1016/j.radonc.2006.08.012. View

Star-Lack J, Adalsteinsson E, Adam M, Terris D, Pinto H, Brown J . In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements. AJNR Am J Neuroradiol. 2000; 21(1):183-93. PMC: 7976356. View

Haase A, Frahm J, Hanicke W, Matthaei D . 1H NMR chemical shift selective (CHESS) imaging. Phys Med Biol. 1985; 30(4):341-4. DOI: 10.1088/0031-9155/30/4/008. View

Star-Lack J, Spielman D, Adalsteinsson E, Kurhanewicz J, Terris D, Vigneron D . In vivo lactate editing with simultaneous detection of choline, creatine, NAA, and lipid singlets at 1.5 T using PRESS excitation with applications to the study of brain and head and neck tumors. J Magn Reson. 1998; 133(2):243-54. DOI: 10.1006/jmre.1998.1458. View

Wang Z, Vigneron D, Miller S, Mukherjee P, Charlton N, Lu Y . Brain metabolite levels assessed by lactate-edited MR spectroscopy in premature neonates with and without pentobarbital sedation. AJNR Am J Neuroradiol. 2008; 29(4):798-801. PMC: 2745552. DOI: 10.3174/ajnr.A0912. View

Haensgen G, Krause U, Becker A, Stadler P, Lautenschlaeger C, Wohlrab W . Tumor hypoxia, p53, and prognosis in cervical cancers. Int J Radiat Oncol Biol Phys. 2001; 50(4):865-72. DOI: 10.1016/s0360-3016(01)01523-1. View

Star-Lack J, Nelson S, Kurhanewicz J, Huang L, Vigneron D . Improved water and lipid suppression for 3D PRESS CSI using RF band selective inversion with gradient dephasing (BASING). Magn Reson Med. 1997; 38(2):311-21. DOI: 10.1002/mrm.1910380222. View

10.

Adalsteinsson E, Spielman D, Wright G, Pauly J, Meyer C, Macovski A . Incorporating lactate/lipid discrimination into a spectroscopic imaging sequence. Magn Reson Med. 1993; 30(1):124-30. DOI: 10.1002/mrm.1910300119. View

11.

Naressi A, Couturier C, Castang I, de Beer R, Graveron-Demilly D . Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Comput Biol Med. 2001; 31(4):269-86. DOI: 10.1016/s0010-4825(01)00006-3. View

12.

Brizel D, Sibley G, Prosnitz L, Scher R, Dewhirst M . Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 1997; 38(2):285-9. DOI: 10.1016/s0360-3016(97)00101-6. View

13.

Edden R, Schar M, Hillis A, Barker P . Optimized detection of lactate at high fields using inner volume saturation. Magn Reson Med. 2006; 56(4):912-7. DOI: 10.1002/mrm.21030. View

14.

Walenta S, Chau T, Schroeder T, Lehr H, Kunz-Schughart L, Fuerst A . Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?. J Cancer Res Clin Oncol. 2003; 129(6):321-6. DOI: 10.1007/s00432-003-0450-x. View

15.

Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P . Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996; 56(19):4509-15. View

16.

Kelley D, Wald L, Star-Lack J . Lactate detection at 3T: compensating J coupling effects with BASING. J Magn Reson Imaging. 1999; 9(5):732-7. DOI: 10.1002/(sici)1522-2586(199905)9:5<732::aid-jmri17>3.0.co;2-q. View

17.

Jouvensal L, Carlier P, Bloch G . Practical implementation of single-voxel double-quantum editing on a whole-body NMR spectrometer: localized monitoring of lactate in the human leg during and after exercise. Magn Reson Med. 1996; 36(3):487-90. DOI: 10.1002/mrm.1910360325. View

18.

Yablonskiy D, Neil J, Raichle M, Ackerman J . Homonuclear J coupling effects in volume localized NMR spectroscopy: pitfalls and solutions. Magn Reson Med. 1998; 39(2):169-78. DOI: 10.1002/mrm.1910390202. View

19.

Lange T, Dydak U, Roberts T, Rowley H, Bjeljac M, Boesiger P . Pitfalls in lactate measurements at 3T. AJNR Am J Neuroradiol. 2006; 27(4):895-901. PMC: 8133981. View

20.

Pauly J, le Roux P, Nishimura D, Macovski A . Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm [NMR imaging]. IEEE Trans Med Imaging. 1991; 10(1):53-65. DOI: 10.1109/42.75611. View