A20: Central Gatekeeper in Inflammation and Immunity

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2008 Nov 15

PMID 19008218

Citations 161

Authors

Beatrice Coornaert

Isabelle Carpentier

Rudi Beyaert

Affiliations

Soon will be listed here.

Abstract

Inappropriate functioning of the immune system is linked to immune deficiency, autoimmune disease, and cancer. It is therefore not surprising that intracellular immune signaling pathways are tightly controlled. One of the best studied transcription factors in immune signaling is NF-kappaB, which is activated by multiple receptors and regulates the expression of a wide variety of proteins that control innate and adaptive immunity. A20 is an early NF-kappaB-responsive gene that encodes a ubiquitin-editing protein that is involved in the negative feedback regulation of NF-kappaB signaling. Here, we discuss the mechanism of action of A20 and its role in the regulation of inflammation and immunity.

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