Decoding and Engineering Tetracycline Biosynthesis

Overview

Journal Metab Eng

Specialties Biomedical Engineering
Endocrinology

Date 2008 Nov 15

PMID 19007902

Citations 16

Authors

Lauren B Pickens

Yi Tang

Affiliations

Soon will be listed here.

Abstract

Tetracyclines have been important agents in combating infectious disease since their discovery in the mid-20th century. Following widespread use, tetracycline resistance mechanisms emerged and continue to create a need for new derivatives that are active against resistant bacterial strains. Semisynthesis has led to second and third generation tetracycline derivatives with enhanced antibiotic activity and pharmacological properties. Recent advancement in understanding of the tetracycline biosynthetic pathway may open the door to broaden the range of tetracycline derivatives and afford analogs that are difficult to access by synthetic chemistry.

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