Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2016 Jul 12

PMID 27399731

Citations 67

Authors

Clement Offret

Florie Desriac

Patrick Le Chevalier

Jerome Mounier

Camille Jegou

Yannick Fleury

Affiliations

Soon will be listed here.

Abstract

This review is dedicated to the antimicrobial metabolite-producing Pseudoalteromonas strains. The genus Pseudoalteromonas hosts 41 species, among which 16 are antimicrobial metabolite producers. To date, a total of 69 antimicrobial compounds belonging to 18 different families have been documented. They are classified into alkaloids, polyketides, and peptides. Finally as Pseudoalteromonas strains are frequently associated with macroorganisms, we can discuss the ecological significance of antimicrobial Pseudoalteromonas as part of the resident microbiota.

Citing Articles

Highly Pleomorphic Strains of the Vibrio Predator and Their Outer Membrane Vesicles: A Scanning Electron Micrographic Study.

Richards G, Uknalis J, Watson M Microorganisms. 2025; 13(2).

PMID: 40005732 PMC: 11858312. DOI: 10.3390/microorganisms13020365.

Strains as Biofilm Control Agents in Aquaculture: Reducing Biofilm Biovolume While Preserving Microbial Diversity.

Leroy G, Parizadeh L, Cuny H, Offret C, Protat M, Bazire A Microorganisms. 2025; 13(2).

PMID: 40005730 PMC: 11858371. DOI: 10.3390/microorganisms13020363.

The Isolation and Identification of sp. H27, a Bacterial Strain Pathogenic to .

Qin H, Jiang J, Jing Z, Wang J, Xu S, Chen R Microorganisms. 2025; 13(2).

PMID: 40005668 PMC: 11857945. DOI: 10.3390/microorganisms13020296.

Genomic insights into the cold adaptation and secondary metabolite potential of sp. WY3 from Antarctic krill.

Wang Y, Xie J, Feng Z, Ma L, Wu W, Guo C Front Microbiol. 2024; 15:1459716.

PMID: 39564484 PMC: 11573776. DOI: 10.3389/fmicb.2024.1459716.

Hatchery type influences the gill microbiome of Atlantic farmed salmon (Salmo salar) after transfer to sea.

Stewart K, Boerlage A, Barr W, Ijaz U, Smith C Anim Microbiome. 2024; 6(1):65.

PMID: 39516952 PMC: 11549768. DOI: 10.1186/s42523-024-00347-y.

References

Holmstrom , Kjelleberg . Marine Pseudoalteromonas species are associated with higher organisms and produce biologically active extracellular agents. FEMS Microbiol Ecol. 1999; 30(4):285-293. DOI: 10.1111/j.1574-6941.1999.tb00656.x. View

Zerikly M, Challis G . Strategies for the discovery of new natural products by genome mining. Chembiochem. 2009; 10(4):625-33. DOI: 10.1002/cbic.200800389. View

Papaleo M, Fondi M, Maida I, Perrin E, Lo Giudice A, Michaud L . Sponge-associated microbial Antarctic communities exhibiting antimicrobial activity against Burkholderia cepacia complex bacteria. Biotechnol Adv. 2011; 30(1):272-93. DOI: 10.1016/j.biotechadv.2011.06.011. View

Katsuyama Y, Ohnishi Y . Type III polyketide synthases in microorganisms. Methods Enzymol. 2012; 515:359-77. DOI: 10.1016/B978-0-12-394290-6.00017-3. View

Ivanova E, Shevchenko L, Sawabe T, Lysenko A, Svetashev V, Gorshkova N . Pseudoalteromonas maricaloris sp. nov., isolated from an Australian sponge, and reclassification of [Pseudoalteromonas aurantia] NCIMB 2033 as Pseudoalteromonas flavipulchra sp. nov. Int J Syst Evol Microbiol. 2002; 52(Pt 1):263-271. DOI: 10.1099/00207713-52-1-263. View

Gerber N . Prodigiosin-like pigments from Actinomadura (Nocardia) pelletieri and Actinomadura madurae. Appl Microbiol. 1969; 18(1):1-3. PMC: 377871. DOI: 10.1128/am.18.1.1-3.1969. View

Yu Z, Zhao D, Ran L, Mi Z, Wu Z, Pang X . Development of a genetic system for the deep-sea psychrophilic bacterium Pseudoalteromonas sp. SM9913. Microb Cell Fact. 2014; 13(1):13. PMC: 3930924. DOI: 10.1186/1475-2859-13-13. View

Isnansetyo A, Kamei Y . MC21-A, a bactericidal antibiotic produced by a new marine bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30(T), against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003; 47(2):480-8. PMC: 151744. DOI: 10.1128/AAC.47.2.480-488.2003. View

Hurdle J, ONeill A, Chopra I . Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. J Antimicrob Chemother. 2004; 54(2):549-52. DOI: 10.1093/jac/dkh352. View

10.

Koglin A, Walsh C . Structural insights into nonribosomal peptide enzymatic assembly lines. Nat Prod Rep. 2009; 26(8):987-1000. PMC: 2773127. DOI: 10.1039/b904543k. View

11.

Zhang X, Nakahara T, Miyazaki M, Nogi Y, Taniyama S, Arakawa O . Diversity and function of aerobic culturable bacteria in the intestine of the sea cucumber Holothuria leucospilota. J Gen Appl Microbiol. 2013; 58(6):447-56. DOI: 10.2323/jgam.58.447. View

12.

Ziemert N, Podell S, Penn K, Badger J, Allen E, Jensen P . The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity. PLoS One. 2012; 7(3):e34064. PMC: 3315503. DOI: 10.1371/journal.pone.0034064. View

13.

Wilson G, Raftos D, Corrigan S, Nair S . Diversity and antimicrobial activities of surface-attached marine bacteria from Sydney Harbour, Australia. Microbiol Res. 2009; 165(4):300-11. DOI: 10.1016/j.micres.2009.05.007. View

14.

Shiozawa H, Shimada A, Takahashi S . Thiomarinols D, E, F and G, new hybrid antimicrobial antibiotics produced by a marine bacterium; isolation, structure, and antimicrobial activity. J Antibiot (Tokyo). 1997; 50(5):449-52. DOI: 10.7164/antibiotics.50.449. View

15.

Faulkner D . Marine natural products. Nat Prod Rep. 2001; 18(1):1-49. DOI: 10.1039/b006897g. View

16.

Kelecom A . Secondary metabolites from marine microorganisms. An Acad Bras Cienc. 2002; 74(1):151-70. DOI: 10.1590/s0001-37652002000100012. View

17.

Vynne N, Mansson M, Nielsen K, Gram L . Bioactivity, chemical profiling, and 16S rRNA-based phylogeny of Pseudoalteromonas strains collected on a global research cruise. Mar Biotechnol (NY). 2011; 13(6):1062-73. DOI: 10.1007/s10126-011-9369-4. View

18.

Challis G, Naismith J . Structural aspects of non-ribosomal peptide biosynthesis. Curr Opin Struct Biol. 2004; 14(6):748-56. PMC: 3326538. DOI: 10.1016/j.sbi.2004.10.005. View

19.

Scheffler R, Colmer S, Tynan H, DEMAIN A, Gullo V . Antimicrobials, drug discovery, and genome mining. Appl Microbiol Biotechnol. 2012; 97(3):969-78. DOI: 10.1007/s00253-012-4609-8. View

20.

Neumann C, Fujimori D, Walsh C . Halogenation strategies in natural product biosynthesis. Chem Biol. 2008; 15(2):99-109. DOI: 10.1016/j.chembiol.2008.01.006. View