Phosphoinositide Phosphatases and Disease

Overview

Journal J Lipid Res

Publisher Elsevier

Specialty Biochemistry

Date 2008 Nov 13

PMID 19001665

Citations 26

Authors

Philip W Majerus

John D York

Affiliations

Soon will be listed here.

Abstract

The field of inositol signaling has expanded greatly in recent years. Given the many reviews on phosphoinositide kinases, we have chosen to restrict our discussion to inositol lipid hydrolysis focused on the phosphatases and a brief mention of the lipase isoforms. We also discuss recent discoveries that link mutations in phosphoinositide phosphatases to disease.

Citing Articles

PI(4,5)P2-dependent and -independent roles of PI4P in the control of hormone secretion by pituitary cells.

Stojilkovic S, Balla T Front Endocrinol (Lausanne). 2023; 14:1118744.

PMID: 36777340 PMC: 9911653. DOI: 10.3389/fendo.2023.1118744.

Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease.

Lete M, Tripathi A, Chandran V, Bankaitis V, McDermott M Adv Biol Regul. 2020; 78:100740.

PMID: 32992233 PMC: 7986245. DOI: 10.1016/j.jbior.2020.100740.

Rendezvous at Plasma Membrane: Cellular Lipids and tRNA Set up Sites of HIV-1 Particle Assembly and Incorporation of Host Transmembrane Proteins.

Thornhill D, Murakami T, Ono A Viruses. 2020; 12(8).

PMID: 32752131 PMC: 7472227. DOI: 10.3390/v12080842.

Characterization of Specific Ion Effects on PI(4,5)P Clustering: Molecular Dynamics Simulations and Graph-Theoretic Analysis.

Han K, Gericke A, Pastor R J Phys Chem B. 2020; 124(7):1183-1196.

PMID: 31994887 PMC: 7461730. DOI: 10.1021/acs.jpcb.9b10951.

Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells.

Hale A, Clarke B, York J Methods Mol Biol. 2019; 2091:83-92.

PMID: 31773572 PMC: 7293352. DOI: 10.1007/978-1-0716-0167-9_7.

References

Nicot A, Laporte J . Endosomal phosphoinositides and human diseases. Traffic. 2008; 9(8):1240-9. PMC: 2607523. DOI: 10.1111/j.1600-0854.2008.00754.x. View

Lemmon M . Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol. 2008; 9(2):99-111. DOI: 10.1038/nrm2328. View

Sakisaka T, Itoh T, Miura K, Takenawa T . Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. Mol Cell Biol. 1997; 17(7):3841-9. PMC: 232236. DOI: 10.1128/MCB.17.7.3841. View

Blagoveshchenskaya A, Cheong F, Rohde H, Glover G, Knodler A, Nicolson T . Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J Cell Biol. 2008; 180(4):803-12. PMC: 2265582. DOI: 10.1083/jcb.200708109. View

Voelker D . Protein and lipid motifs regulate phosphatidylserine traffic in yeast. Biochem Soc Trans. 2005; 33(Pt 5):1141-5. DOI: 10.1042/BST20051141. View

Odorizzi G, Babst M, Emr S . Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem Sci. 2000; 25(5):229-35. DOI: 10.1016/s0968-0004(00)01543-7. View

Kutateladze T . Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain. Biochim Biophys Acta. 2006; 1761(8):868-77. PMC: 2740714. DOI: 10.1016/j.bbalip.2006.03.011. View

Norris F, Atkins R, MAJERUS P . The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem. 1997; 272(38):23859-64. DOI: 10.1074/jbc.272.38.23859. View

Paolo G, De Camilli P . Phosphoinositides in cell regulation and membrane dynamics. Nature. 2006; 443(7112):651-7. DOI: 10.1038/nature05185. View

10.

Dove S, Cooke F, Douglas M, Sayers L, Parker P, Michell R . Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis. Nature. 1997; 390(6656):187-92. DOI: 10.1038/36613. View

11.

Roberts H, Clarke J, Letcher A, Irvine R, Hinchliffe K . Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines. FEBS Lett. 2005; 579(13):2868-72. DOI: 10.1016/j.febslet.2005.04.027. View

12.

Mani M, Lee S, Lucast L, Cremona O, Paolo G, De Camilli P . The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals. Neuron. 2007; 56(6):1004-18. PMC: 3653591. DOI: 10.1016/j.neuron.2007.10.032. View

13.

Astle M, Horan K, Ooms L, Mitchell C . The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?. Biochem Soc Symp. 2007; (74):161-81. DOI: 10.1042/BSS0740161. View

14.

Dowler S, Currie R, Campbell D, Deak M, Kular G, Downes C . Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 2000; 351(Pt 1):19-31. PMC: 1221362. DOI: 10.1042/0264-6021:3510019. View

15.

Caldwell K, Lips D, Bansal V, MAJERUS P . Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. J Biol Chem. 1991; 266(27):18378-86. View

16.

Liu Y, Boukhelifa M, Tribble E, Morin-Kensicki E, Uetrecht A, Bear J . The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals. Mol Biol Cell. 2008; 19(7):3080-96. PMC: 2441670. DOI: 10.1091/mbc.e07-12-1290. View

17.

Cleves A, Novick P, Bankaitis V . Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. J Cell Biol. 1989; 109(6 Pt 1):2939-50. PMC: 2115899. DOI: 10.1083/jcb.109.6.2939. View

18.

Cooke F, Dove S, McEwen R, Painter G, Holmes A, Hall M . The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae. Curr Biol. 1998; 8(22):1219-22. DOI: 10.1016/s0960-9822(07)00513-1. View

19.

Chung J, Sekiya F, Kang H, Lee C, Han J, Kim S . Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 1997; 272(25):15980-5. DOI: 10.1074/jbc.272.25.15980. View

20.

Suh B, Inoue T, Meyer T, Hille B . Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science. 2006; 314(5804):1454-7. PMC: 3579521. DOI: 10.1126/science.1131163. View