A 22-y Prospective Study of Fish Intake in Relation to Prostate Cancer Incidence and Mortality

Overview

Journal Am J Clin Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 2008 Nov 11

PMID 18996866

Citations 47

Authors

Jorge E Chavarro

Meir J Stampfer

Megan N Hall

Howard D Sesso

Jing Ma

Affiliations

Soon will be listed here.

Abstract

Background: Fish and seafood n-3 fatty acids may prevent or delay the progression of prostate cancer, but epidemiologic studies do not uniformly support this hypothesis.

Objective: We examined the relation of fish and seafood n-3 fatty acid intakes with prostate cancer incidence and mortality.

Design: We conducted a prospective cohort study among 20,167 men participating in the Physician's Health Study who were free of cancer in 1983.

Results: During 382 144 person-years of follow-up, 2161 men were diagnosed with prostate cancer and 230 died of prostate cancer. Fish intake was unrelated to prostate cancer incidence. Survival analysis among the men diagnosed with prostate cancer revealed that those consuming fish >or=5 times/wk had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly [relative risk (RR) = 0.52; 95% CI: 0.30, 0.91; P for trend = 0.05]. A similar association was found between seafood n-3 fatty acid intake and prostate cancer mortality (RR(Q5 versus Q1) = 0.64; 95% CI: 0.42, 0.99; P for trend = 0.02). These associations became stronger when the analyses were restricted to clinically detected cases.

Conclusion: These results suggest that fish intake is unrelated to prostate cancer incidence but may improve prostate cancer survival.

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References

Close D, Kristal A, Li S, Patterson R, White E . Associations of demographic and health-related characteristics with prostate cancer screening in Washington State. Cancer Epidemiol Biomarkers Prev. 1998; 7(7):627-30. View

Connolly J, Coleman M, Rose D . Effects of dietary fatty acids on DU145 human prostate cancer cell growth in athymic nude mice. Nutr Cancer. 1997; 29(2):114-9. DOI: 10.1080/01635589709514611. View

Schuurman A, van den Brandt P, Dorant E, Goldbohm R . Animal products, calcium and protein and prostate cancer risk in The Netherlands Cohort Study. Br J Cancer. 1999; 80(7):1107-13. PMC: 2363036. DOI: 10.1038/sj.bjc.6690472. View

Deneo-Pellegrini H, De Stefani E, Ronco A, Mendilaharsu M . Foods, nutrients and prostate cancer: a case-control study in Uruguay. Br J Cancer. 1999; 80(3-4):591-7. PMC: 2362326. DOI: 10.1038/sj.bjc.6690396. View

Schuurman A, van den Brandt P, Dorant E, Brants H, Goldbohm R . Association of energy and fat intake with prostate carcinoma risk: results from The Netherlands Cohort Study. Cancer. 1999; 86(6):1019-27. View

Freeman V, Meydani M, Hur K, Flanigan R . Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma. Cancer. 2004; 101(12):2744-54. DOI: 10.1002/cncr.20676. View

Vang K, Ziboh V . 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2005; 72(5):363-72. DOI: 10.1016/j.plefa.2005.02.002. View

Chan J, Gann P, Giovannucci E . Role of diet in prostate cancer development and progression. J Clin Oncol. 2005; 23(32):8152-60. DOI: 10.1200/JCO.2005.03.1492. View

Sundaram S, Ghosh J . Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival. Biochem Biophys Res Commun. 2005; 339(1):93-8. DOI: 10.1016/j.bbrc.2005.10.189. View

10.

Chan J, Holick C, Leitzmann M, Rimm E, Willett W, Stampfer M . Diet after diagnosis and the risk of prostate cancer progression, recurrence, and death (United States). Cancer Causes Control. 2006; 17(2):199-208. DOI: 10.1007/s10552-005-0413-4. View

11.

Giovannucci E, Liu Y, Stampfer M, Willett W . A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006; 15(2):203-10. DOI: 10.1158/1055-9965.EPI-05-0586. View

12.

Kelavkar U, Hutzley J, Dhir R, Kim P, Allen K, McHugh K . Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy. Neoplasia. 2006; 8(2):112-24. PMC: 1578514. DOI: 10.1593/neo.05637. View

13.

Freeman V, Flanigan R, Meydani M . Prostatic fatty acids and cancer recurrence after radical prostatectomy for early-stage prostate cancer. Cancer Causes Control. 2007; 18(2):211-8. DOI: 10.1007/s10552-006-0095-6. View

14.

Rohrmann S, Platz E, Kavanaugh C, Thuita L, Hoffman S, Helzlsouer K . Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. Cancer Causes Control. 2007; 18(1):41-50. DOI: 10.1007/s10552-006-0082-y. View

15.

Mitrou P, Albanes D, Weinstein S, Pietinen P, Taylor P, Virtamo J . A prospective study of dietary calcium, dairy products and prostate cancer risk (Finland). Int J Cancer. 2007; 120(11):2466-73. DOI: 10.1002/ijc.22553. View

16.

Chavarro J, Stampfer M, Li H, Campos H, Kurth T, Ma J . A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2007; 16(7):1364-70. DOI: 10.1158/1055-9965.EPI-06-1033. View

17.

Crowe F, Key T, Appleby P, Travis R, Overvad K, Jakobsen M . Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 2008; 87(5):1405-13. DOI: 10.1093/ajcn/87.5.1405. View

18.

McEntee M, Ziegler C, Reel D, Tomer K, Shoieb A, Ray M . Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. Am J Pathol. 2008; 173(1):229-41. PMC: 2438300. DOI: 10.2353/ajpath.2008.070989. View

19.

Carmody J, Olendzki B, Reed G, Andersen V, Rosenzweig P . A dietary intervention for recurrent prostate cancer after definitive primary treatment: results of a randomized pilot trial. Urology. 2008; 72(6):1324-8. DOI: 10.1016/j.urology.2008.01.015. View

20.

Littman A, Kristal A, White E . Recreational physical activity and prostate cancer risk (United States). Cancer Causes Control. 2006; 17(6):831-41. DOI: 10.1007/s10552-006-0024-8. View