Drusen Are Associated with Local and Distant Disruptions to Human Retinal Pigment Epithelium Cells

Overview

Journal Exp Eye Res

Specialty Ophthalmology

Date 2008 Nov 11

PMID 18992244

Citations 27

Authors

Heba Al-Hussaini

Matthew Schneiders

Peter Lundh

Glen Jeffery

Affiliations

Soon will be listed here.

Abstract

Drusen are extra-cellular deposits that form between the retinal pigment epithelium (RPE) and Bruch's membrane (BM). Numerous and/or confluent drusen are a significant risk factor for age-related macular degeneration (AMD). Here, using whole mounted human RPE preparation we show that RPE cell morphology changes in association with drusen. These changes included an increase in cell size and distortion in the regularity of their distribution. Further, although binucleation is relatively rare in human RPE, there was a marked increase in the number of binucleated RPE cell associated with individual druse. Surprisingly many of these changes were found at distances up to 400 microm from drusen.

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