Retinal Pigment Epithelium Transplantation: Past, Present, and Future

Overview

Journal J Ophthalmic Vis Res

Specialty Ophthalmology

Date 2023 Jan 9

PMID 36620704

Authors

Ayyad Zartasht Khan

Tor Paaske Utheim

Jon Roger Eidet

Affiliations

Soon will be listed here.

Abstract

Retinal pigment epithelium (RPE) is a monolayer of cells situated between photoreceptors and the underlying choroid. It is essential for normal retinal function. Damaged RPE is associated with diseases such as age-related macular degeneration, Stargardt's macular dystrophy, and retinitis pigmentosa. RPE cells can easily be visualized , sustainable , and differentiated from stem cells with a relatively straightforward protocol. Due to these properties and the clinical significance of this epithelium in various retinal diseases, RPE transplantation as a treatment modality has gained considerable interest in the last decade. This paper presents the main techniques for RPE transplantation and discusses recent clinically relevant publications.

Citing Articles

The New Era of Therapeutic Strategies for the Treatment of Retinitis Pigmentosa: A Narrative Review of Pathomolecular Mechanisms for the Development of Cell-Based Therapies.

Becherucci V, Bacci G, Marziali E, Sodi A, Bambi F, Caputo R Biomedicines. 2023; 11(10).

PMID: 37893030 PMC: 10604477. DOI: 10.3390/biomedicines11102656.

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