A New Cytotoxic Guaianolide from Chrysanthemum Boreale

Overview

Journal Fitoterapia

Publisher Elsevier

Specialties Pharmacology
Rehabilitation Medicine

Date 2008 Nov 6

PMID 18983901

Citations 2

Authors

Ki Hun Park

Min Suk Yang

Moon Ki Park

Sang Chan Kim

Chae Ha Yang

Sook Jahr Park

Jong Rok Lee

Affiliations

Soon will be listed here.

Abstract

A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound 1 exhibited cytotoxic activity (IC(50)< or =4 microg/ml) against all five human cancer cell lines tested.

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