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Time Course of Regional Brain Activation Associated with Onset of Auditory/verbal Hallucinations

Overview
Journal Br J Psychiatry
Publisher Cambridge University Press
Specialty Psychiatry
Date 2008 Nov 4
PMID 18978327
Citations 38
Authors
Ralph E Hoffman
Adam W Anderson
Maxine Varanko
John C Gore
Michelle Hampson
Affiliations
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Abstract

The time course of brain activation prior to onset of auditory/verbal hallucinations was characterised using functional magnetic resonance imaging in six dextral patients with schizophrenia. Composite maps of pre-hallucination periods revealed activation in the left anterior insula and in the right middle temporal gyrus, partially replicating two previous case reports, as well as deactivation in the anterior cingulate and parahippocampal gyri. These findings may reflect brain events that trigger or increase vulnerability to auditory/verbal hallucinations.

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