Ralph E Hoffman
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Explore the profile of Ralph E Hoffman including associated specialties, affiliations and a list of published articles.
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22
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Recent Articles
1.
Ford J, Morris S, Hoffman R, Sommer I, Waters F, McCarthy-Jones S, et al.
Schizophr Bull
. 2014 May;
40 Suppl 4:S295-304.
PMID: 24847862
We explore how hallucinations might be studied within the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) framework, which asks investigators to step back from diagnoses based on...
2.
Hoffman R, Wu K, Pittman B, Cahill J, Hawkins K, Fernandez T, et al.
Biol Psychiatry
. 2013 Mar;
73(10):1008-14.
PMID: 23485015
Background: Auditory/verbal hallucinations (AVHs) are accompanied by activation in Wernicke's and right homologous regions. Efficacy in curtailing AVHs via 1-Hz repetitive magnetic stimulation (rTMS) targeting a site in each region...
3.
Hoffman R, Hampson M
Front Hum Neurosci
. 2012 Mar;
6:6.
PMID: 22375109
Functional connectivity (FC) studies of brain mechanisms leading to auditory verbal hallucinations (AVHs) utilizing functional magnetic resonance imaging (fMRI) data are reviewed. Initial FC studies utilized fMRI data collected during...
4.
Hoffman R, Pittman B, Constable R, Bhagwagar Z, Hampson M
Br J Psychiatry
. 2011 Oct;
198(4):277-83.
PMID: 21972276
Background: The pathophysiology of auditory verbal hallucinations remains poorly understood. Aims: To characterise the time course of regional brain activity leading to auditory verbal hallucinations. Method: During functional magnetic resonance...
5.
Hoffman R, Grasemann U, Gueorguieva R, Quinlan D, Lane D, Miikkulainen R
Biol Psychiatry
. 2011 Mar;
69(10):997-1005.
PMID: 21397213
Background: Various malfunctions involving working memory, semantics, prediction error, and dopamine neuromodulation have been hypothesized to cause disorganized speech and delusions in schizophrenia. Computational models may provide insights into why...
6.
Hoffman R, Fernandez T, Pittman B, Hampson M
Biol Psychiatry
. 2010 Dec;
69(5):407-14.
PMID: 21145042
Background: Higher levels of inter-region functional coordination can facilitate emergence of neural activity as conscious percepts. We consequently tested the hypothesis that auditory/verbal hallucinations (AVHs) arise from elevated functional coordination...
7.
Ford J, Roach B, Miller R, Duncan C, Hoffman R, Mathalon D
Int J Psychophysiol
. 2010 Jun;
78(1):3-13.
PMID: 20580752
Introduction: Reduction of P300 event-related potential amplitude in schizophrenia is perhaps the most replicated biological reflection of the illness. P300 is typically elicited by infrequent deviant events that are imbedded...
8.
Hoffman R
Schizophr Bull
. 2010 Apr;
36(3):440-2.
PMID: 20363873
Silvano Arieti proposed that auditory/verbal hallucinations (AVHs) are triggered by momentary states of heightened auditory attention that he identified as a "listening attitude." Studies and clinical observations by our group...
9.
Mathalon D, Hoffman R, Watson T, Miller R, Roach B, Ford J
Front Hum Neurosci
. 2010 Feb;
3:70.
PMID: 20140266
Schizoaffective disorder (SA) is distinguished from schizophrenia (SZ) based on the presence of prominent mood symptoms over the illness course. Despite this clinical distinction, SA and SZ patients are often...
10.
Krystal J, Tolin D, Sanacora G, Castner S, Williams G, Aikins D, et al.
Drug Discov Today
. 2009 May;
14(13-14):690-7.
PMID: 19460458
Current treatments for psychiatric disorders were developed with the aim of providing symptomatic relief rather than reversing underlying abnormalities in neuroplasticity or neurodevelopment that might contribute to psychiatric disorders. This...