TGF-beta: Upregulator of HIV Replication in Macrophages

Overview

Journal Res Virol

Publisher Elsevier

Specialty Microbiology

Date 1991 Mar 1

PMID 1896646

Citations 3

Authors

J K Lazdins

T Klimkait

E Alteri

M Walker

D Cox

G Bilbe

R Shipman

N Cerletti

G McMaster

Affiliations

Soon will be listed here.

Abstract

TGF-beta at physiological concentrations, when added to monocyte-derived macrophages following HIV1 infection, has an enhancing effect upon the rate of virus production. This effect is observed with the monocytotropic isolate ADA, as well as with HIV1 IIIB, which poorly replicates in macrophages.

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