Lipid Lowering Activity of Anthocephalus Indicus Root in Hyperlipidemic Rats

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2008 Oct 29

PMID 18955320

Citations 9

Authors

Vishnu Kumar

Mohammad Mubin Khan

Ashok Kumar Khanna

Ranjana Singh

Sushma Singh

Ramesh Chander

Farzana Mahdi

Abbas Ali Mahdi

Jitendra Kumar Saxena

Raj Kumar Singh

Affiliations

Soon will be listed here.

Abstract

The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg(-1) b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50-500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.

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