Dietary Habits and Prostate Cancer Detection: a Case-control Study

Overview

Journal Can Urol Assoc J

Specialty Urology

Date 2008 Oct 28

PMID 18953447

Citations 16

Authors

Moamen Amin

Suganthiny Jeyaganth

Nader Fahmy

Louis R Begin

Samuel Aronson

Stephen Jacobson

Simon Tanguay

Wassim Kassouf

Armen Aprikian

Affiliations

Soon will be listed here.

Abstract

Background: Many studies have suggested that nutritional factors may affect prostate cancer development. The aim of our study was to evaluate the relationship between dietary habits and prostate cancer detection.

Methods: We studied 917 patients who planned to have transrectal ultrasonography-guided prostatic biopsy based on an elevated serum prostate-specific antigen (PSA) level, a rising serum PSA level or an abnormal digital rectal examination. Before receiving the results of their biopsy, all patients answered a self-administered food frequency questionnaire. In combination with pathology data we performed univariable and multivariable logistic regression analyses for the predictors of cancer and its aggressiveness.

Results: Prostate cancer was found in 42% (386/917) of patients. The mean patient age was 64.5 (standard deviation [SD] 8.3) years and the mean serum PSA level for prostate cancer and benign cases, respectively, was 13.4 (SD 28.2) mug/L and 7.3 (SD 4.9) mug/L. Multivariable analysis revealed that a meat diet (e.g., red meat, ham, sausages) was associated with an increased risk of prostate cancer (odds ratio [OR] 2.91, 95% confidence interval [CI] 1.55-4.87, p = 0.027) and a fish diet was associated with less prostate cancer (OR 0.54, 95% CI 0.32-0.89, p = 0.017). Aggressive tumours were defined by Gleason score (>/= 7), serum PSA level (>/= 10 mug/L) and the number of positive cancer cores (>/= 3). None of the tested dietary components were found to be associated with prostate cancer aggressivity.

Conclusion: Fish diets appear to be associated with less risk of prostate cancer detection, and meat diets appear to be associated with a 3-fold increased risk of prostate cancer. These observations add to the growing body of evidence suggesting a relationship between diet and prostate cancer risk.

Citing Articles

Fish consumption and risk of prostate cancer or its mortality: an updated systematic review and dose-response meta-analysis of prospective cohort studies.

Eshaghian N, Heidarzadeh-Esfahani N, Akbari H, Askari G, Sadeghi O Front Nutr. 2023; 10:1221029.

PMID: 37593679 PMC: 10427873. DOI: 10.3389/fnut.2023.1221029.

Dietary Factors and Prostate Cancer Development, Progression, and Reduction.

Oczkowski M, Dziendzikowska K, Pasternak-Winiarska A, Wlodarek D, Gromadzka-Ostrowska J Nutrients. 2021; 13(2).

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Prostate Cancer Disparity, Chemoprevention, and Treatment by Specific Medicinal Plants.

Yedjou C, Mbemi A, Noubissi F, Tchounwou S, Tsabang N, Payton M Nutrients. 2019; 11(2).

PMID: 30720759 PMC: 6412894. DOI: 10.3390/nu11020336.

Prostate Cancer Incidence is Correlated to Total Meat Intake– a Cross-National Ecologic Analysis of 172 Countries.

You W, Henneberg M Asian Pac J Cancer Prev. 2018; 19(8):2229-2239.

PMID: 30139230 PMC: 6171413. DOI: 10.22034/APJCP.2018.19.8.2229.

Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid.

Alisson-Silva F, Kawanishi K, Varki A Mol Aspects Med. 2016; 51:16-30.

PMID: 27421909 PMC: 5035214. DOI: 10.1016/j.mam.2016.07.002.

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