UCbase & MiRfunc: a Database of Ultraconserved Sequences and MicroRNA Function

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2008 Oct 24

PMID 18945703

Citations 17

Authors

Cristian Taccioli

Enrica Fabbri

Rosa Visone

Stefano Volinia

George A Calin

Louise Y Fong

Roberto Gambari

Arianna Bottoni

Mario Acunzo

John Hagan

Marilena V Iorio

Claudia Piovan

Giulia Romano

Carlo Maria Croce

Affiliations

Soon will be listed here.

Abstract

Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.

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