Otitis Media As a Presenting Complaint in Childhood Immunodeficiency Diseases

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2008 Oct 23

PMID 18940144

Citations 5

Authors

Nevin W Wilson

Mary Beth Hogan

Affiliations

Soon will be listed here.

Abstract

Otitis media is one of the most common childhood infections and may result from a variety of underlying problems. Suspicion of immunodeficiency should increase when ear infections are frequent; suppurative; unresponsive to antibiotics; caused by unusual organisms; or seen in the context of other frequent infections, severe eczema, or failure to thrive. Humoral immune deficiencies, particularly with an inability to make antibody to encapsulated organisms, are the immunodeficiencies most likely to cause increased otitis media. Immune system evaluation should concentrate on humoral immunodeficiency disorders, but the presenting history and physical findings also should be considered when designing the work-up. Treating the underlying immune deficiency is usually necessary to adequately control the ear infections.

Citing Articles

Phenotypes of 126 Moroccan HIES patients according to NIH Score.

Fadil I, Benhsaien I, El Bakkouri J, Jeddane L, Benaajiba N, Rada N Tunis Med. 2024; 102(10):696-701.

PMID: 39441153 PMC: 11574375. DOI: 10.62438/tunismed.v102i10.5148.

Fusobacterium necrophorum an Underrecognized Cause of Petrous Apicitis Presenting with Gradenigo Syndrome: A Case Report.

Ibrahim Z, Fox-Lewis S, Correia J Am J Case Rep. 2024; 25:e942652.

PMID: 38319911 PMC: 10862527. DOI: 10.12659/AJCR.942652.

Clinical Manifestation of Hyper IgE Syndrome Including Otitis Media.

Wu J, Hong L, Chen T Curr Allergy Asthma Rep. 2018; 18(10):51.

PMID: 30112673 DOI: 10.1007/s11882-018-0806-6.

Otitis media.

Schilder A, Chonmaitree T, Cripps A, Rosenfeld R, Casselbrant M, Haggard M Nat Rev Dis Primers. 2016; 2:16063.

PMID: 27604644 PMC: 7097351. DOI: 10.1038/nrdp.2016.63.

Should newborns be screened for immunodeficiency?: lessons learned from infants with recurrent otitis media.

Yilmaz-Demirdag Y Curr Allergy Asthma Rep. 2011; 11(6):491-8.

PMID: 21901305 DOI: 10.1007/s11882-011-0221-8.

References

Haddad Jr J, Brager R, BLUESTONE C . Infections of the ears, nose, and throat in children with primary immunodeficiencies. Arch Otolaryngol Head Neck Surg. 1992; 118(2):138-41. DOI: 10.1001/archotol.1992.01880020030011. View

French M, Denis K, Dawkins R, Peter J . Severity of infections in IgA deficiency: correlation with decreased serum antibodies to pneumococcal polysaccharides and decreased serum IgG2 and/or IgG4. Clin Exp Immunol. 1995; 100(1):47-53. PMC: 1534280. DOI: 10.1111/j.1365-2249.1995.tb03602.x. View

Yarmohammadi H, Estrella L, Doucette J, Cunningham-Rundles C . Recognizing primary immune deficiency in clinical practice. Clin Vaccine Immunol. 2006; 13(3):329-32. PMC: 1391953. DOI: 10.1128/CVI.13.3.329-332.2006. View

Bulut Y, Guven M, Otlu B, Yenisehirli G, Aladag I, Eyibilen A . Acute otitis media and respiratory viruses. Eur J Pediatr. 2006; 166(3):223-8. PMC: 7086696. DOI: 10.1007/s00431-006-0233-x. View

Lim D . Functional morphology of the mucosa of the middle ear and Eustachian tube. Ann Otol Rhinol Laryngol. 1976; 85(2 Suppl 25 Pt 2):36-43. DOI: 10.1177/00034894760850S209. View

Ogershok P, Hogan M, Welch J, Corder W, Wilson N . Spectrum of illness in pediatric common variable immunodeficiency. Ann Allergy Asthma Immunol. 2006; 97(5):653-6. DOI: 10.1016/S1081-1206(10)61096-4. View

Jaatinen T, Ruuskanen O, Truedsson L, Lokki M . Homozygous deletion of the CYP21A-TNXA-RP2-C4B gene region conferring C4B deficiency associated with recurrent respiratory infections. Hum Immunol. 1999; 60(8):707-14. DOI: 10.1016/s0198-8859(99)00047-6. View

Barnett E, Klein J, Pelton S, Luginbuhl L . Otitis media in children born to human immunodeficiency virus-infected mothers. Pediatr Infect Dis J. 1992; 11(5):360-4. DOI: 10.1097/00006454-199205000-00004. View

Brandtzaeg P, Karlsson G, Hansson G, Petruson B, Bjorkander J, Hanson L . The clinical condition of IgA-deficient patients is related to the proportion of IgD- and IgM-producing cells in their nasal mucosa. Clin Exp Immunol. 1987; 67(3):626-36. PMC: 1542640. View

10.

Monfort-Gouraud M, Vignon C, Vincens A, Blouin J, Fremeaux-Bacchi V, Talon P . [Complement factor I deficiency revealed by repeated systemic Streptococcus pneumoniae infection]. Arch Pediatr. 2006; 13(8):1125-8. DOI: 10.1016/j.arcped.2006.04.023. View

11.

Berman S, Byrns P, Bondy J, Smith P, Lezotte D . Otitis media-related antibiotic prescribing patterns, outcomes, and expenditures in a pediatric medicaid population. Pediatrics. 1997; 100(4):585-92. DOI: 10.1542/peds.100.4.585. View

12.

Epstein M, Gruskay F . Selective deficiency in pneumococcal antibody response in children with recurrent infections. Ann Allergy Asthma Immunol. 1995; 75(2):125-31. View

13.

Cunningham-Rundles C, Bodian C . Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999; 92(1):34-48. DOI: 10.1006/clim.1999.4725. View

14.

Prellner K, Kalm O, Harsten G, Heldrup J, Oxelius V . Pneumococcal serum antibody concentrations during the first three years of life: a study of otitis-prone and non-otitis-prone children. Int J Pediatr Otorhinolaryngol. 1989; 17(3):267-79. DOI: 10.1016/0165-5876(89)90052-9. View

15.

Winkelstein J, Marino M, Ochs H, Fuleihan R, Scholl P, Geha R . The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. Medicine (Baltimore). 2003; 82(6):373-84. DOI: 10.1097/01.md.0000100046.06009.b0. View

16.

Post J, Stoodley P, Hall-Stoodley L, Ehrlich G . The role of biofilms in otolaryngologic infections. Curr Opin Otolaryngol Head Neck Surg. 2004; 12(3):185-90. DOI: 10.1097/01.moo.0000124936.46948.6a. View

17.

Smirnova M, Birchall J, Pearson J . The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediators Inflamm. 2004; 13(2):75-88. PMC: 1781541. DOI: 10.1080/09629350410001688477. View

18.

Blayney A, BUNCH C . Mastoid surgery in chronic granulomatous disease. J Laryngol Otol. 1984; 98(2):187-8. DOI: 10.1017/s0022215100146390. View

19.

Chantry C, Howard C, Auinger P . Full breastfeeding duration and associated decrease in respiratory tract infection in US children. Pediatrics. 2006; 117(2):425-32. DOI: 10.1542/peds.2004-2283. View

20.

Garty B, Conley M, Douglas S, Kolski G . Recurrent infections and staphylococcal liver abscess in a child with C1r deficiency. J Allergy Clin Immunol. 1987; 80(4):631-5. DOI: 10.1016/0091-6749(87)90018-2. View