MTOR Signaling: RAG GTPases Transmit the Amino Acid Signal

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2008 Oct 22

PMID 18929489

Citations 24

Authors

Reuben J Shaw

Affiliations

Soon will be listed here.

Abstract

mTOR (mammalian target of rapamycin) is a highly conserved nutrient-responsive regulator of cell growth that is found in all eukaryotes. The mechanism by which amino acids signal to mTOR has remained one of the largest outstanding questions in the field. Two recent complimentary studies provide compelling evidence that the Rag family of small GTPases is both necessary and sufficient to transmit a positive signal from amino acids to mTOR.

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