Studies on Acute Disseminated Encephalomyelitis Produced Experimentally in Rhesus Monkeys

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1948 Oct 1

PMID 18884901

Citations 18

Authors

E A KABAT

A Wolf

A E BEZER

Affiliations

Soon will be listed here.

Abstract

The factor in brain tissue which induces acute disseminated encephalomyelitis, when injected into rhesus monkeys as an emulsion with adjuvants, has been found in human, monkey, rabbit, and chicken brain but is absent from frog and fish brain. It is unaffected by fixation of the brain in formalin, by boiling, and by treatment with ultrasound. It is present in the spinal cord of 3 day old rabbits but does not appear in the rabbit cerebrum until about the 12th day of life; in this respect it parallels the laying down of myelin. Attempts to produce the encephalomyelitis passively with large quantities of serum or of cell exudates, and suspensions of cells from spleen and lymph node from monkeys with encephalomyelitis, were unsuccessful.

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A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY.

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Studies on acute disseminated encephalomyelitis produced experimentally in Rhesus monkeys; complement-fixing antibodies.

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References

KABAT E, Wolf A, BEZER A . Rapid Production of Acute Disseminated Encephalomyelitis in Rhesus Monkeys by Injection of Brain Tissue With Adjuvants. Science. 1946; 104(2703):362-3. DOI: 10.1126/science.104.2703.362. View

SCHWENTKER F, Rivers T . THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAIN. J Exp Med. 2009; 60(5):559-74. PMC: 2132434. DOI: 10.1084/jem.60.5.559. View

Rivers T, SCHWENTKER F . ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS. J Exp Med. 2009; 61(5):689-702. PMC: 2133246. DOI: 10.1084/jem.61.5.689. View

MORGAN I . ALLERGIC ENCEPHALOMYELITIS IN MONKEYS IN RESPONSE TO INJECTION OF NORMAL MONKEY NERVOUS TISSUE. J Exp Med. 2009; 85(1):131-40. PMC: 2135671. DOI: 10.1084/jem.85.1.131. View

Kolb L, Bolton B . ANTIBODIES TO BRAIN AND THEIR RELATION TO DEMYELINIZATION. J Neurol Psychiatry. 2011; 3(2):111-4. PMC: 1088175. DOI: 10.1136/jnnp.3.2.111. View