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Antigen Delivery Systems for Veterinary Vaccine Development. Viral-vector Based Delivery Systems

Abstract

The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the rational design of vaccines effective against viral epizootic diseases. This paper reviews most of the viral-vector based antigen delivery systems (ADSs) recently developed for vaccine testing in veterinary species, including attenuated virus and DNA and RNA viral vectors. Besides their usefulness in vaccinology, these ADSs constitute invaluable tools to researchers for understanding the nature of protective responses in different species, opening the possibility of modulating or potentiating relevant immune mechanisms involved in protection.

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References
1.
Kerr P, Jackson R . Myxoma virus as a vaccine vector for rabbits: antibody levels to influenza virus haemagglutinin presented by a recombinant myxoma virus. Vaccine. 1995; 13(17):1722-6. DOI: 10.1016/0264-410x(95)00113-f. View

2.
Blakqori G, Weber F . Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs. J Virol. 2005; 79(16):10420-8. PMC: 1182624. DOI: 10.1128/JVI.79.16.10420-10428.2005. View

3.
Swayne D, Beck J, Mickle T . Efficacy of recombinant fowl poxvirus vaccine in protecting chickens against a highly pathogenic Mexican-origin H5N2 avian influenza virus. Avian Dis. 1998; 41(4):910-22. View

4.
Thiel V, Herold J, Schelle B, Siddell S . Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virus. J Gen Virol. 2001; 82(Pt 6):1273-1281. DOI: 10.1099/0022-1317-82-6-1273. View

5.
Qingzhong Y, Barrett T, Brown T, Cook J, Green P, Skinner M . Protection against turkey rhinotracheitis pneumovirus (TRTV) induced by a fowlpox virus recombinant expressing the TRTV fusion glycoprotein (F). Vaccine. 1994; 12(6):569-73. DOI: 10.1016/0264-410x(94)90319-0. View