TRIM Family Proteins and Their Emerging Roles in Innate Immunity

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2008 Oct 7

PMID 18836477

Citations 568

Authors

Keiko Ozato

Dong-Mi Shin

Tsung-Hsien Chang

Herbert C Morse 3rd

Affiliations

Soon will be listed here.

Abstract

The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now more than 60 TRIM proteins known in humans and mice. Many TRIM proteins are induced by type I and type II interferons, which are crucial for many aspects of resistance to pathogens, and several are known to be required for the restriction of infection by lentiviruses. In this Review, we describe recent data that reveal broader antiviral and antimicrobial activities of TRIM proteins and discuss their involvement in the regulation of pathogen-recognition and transcriptional pathways in host defence.

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