Questioning the Role of Rebound Firing in the Cerebellum

Overview

Journal Nat Neurosci

Date 2008 Sep 30

PMID 18820695

Citations 71

Authors

Karina Alvina

Joy T Walter

Adam Kohn

Graham Ellis-Davies

Kamran Khodakhah

Affiliations

Soon will be listed here.

Abstract

A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

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