Synthesis of Potent Water-soluble Tissue Transglutaminase Inhibitors

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2008 Sep 25

PMID 18812257

Citations 26

Authors

Martin Griffin

Alexandre Mongeot

Russell Collighan

Robert E Saint

Richard A Jones

Ian G C Coutts

Daniel L Rathbone

Affiliations

Soon will be listed here.

Abstract

Dipeptide-based sulfonium peptidylmethylketones derived from 6-diazo-5-oxo-L-norleucine (DON) have been investigated as potential water-soluble inhibitors of extracellular transglutaminase. The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase.

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