Human Papillomavirus-related Diseases: Oropharynx Cancers and Potential Implications for Adolescent HPV Vaccination

Overview

Journal J Adolesc Health

Publisher Elsevier

Specialty Pediatrics

Date 2008 Oct 1

PMID 18809146

Citations 33

Authors

Maura L Gillison

Affiliations

Soon will be listed here.

Abstract

Molecular and epidemiological data now support an etiologic role for oncogenic human papillomavirus (HPV) in oral cancers in women and men. Recent studies have demonstrated an increase in the incidence of HPV-associated oral cancers in the United States. Moreover, the incidence rates for these cancers are higher in men than women. Oral HPV infections acquired through oral sex appear to be the principal risk factor for HPV-associated oral cancers. Despite reports in the popular press that the prevalence of oral sexual behaviors is increasing in the adolescent population, trends in these behaviors over time are largely unavailable. However, data indicate that oral-genital contact is frequently practiced among adolescents; adolescents do not typically consider this a risky behavior. The majority of oral cancers (approximately 90%) caused by HPV are identified as HPV 16 positive. Therefore, HPV-associated oral cancers could be prevented by a prophylactic vaccine if the vaccine were demonstrated to be capable of preventing oral HPV 16 infection. These findings have created new potential opportunities for the primary prevention of oral cancers.

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References

Kreimer A, Alberg A, Daniel R, Gravitt P, Viscidi R, Garrett E . Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J Infect Dis. 2004; 189(4):686-98. DOI: 10.1086/381504. View

DSouza G, Fakhry C, Sugar E, Seaberg E, Weber K, Minkoff H . Six-month natural history of oral versus cervical human papillomavirus infection. Int J Cancer. 2007; 121(1):143-50. DOI: 10.1002/ijc.22667. View

Ritchie J, Smith E, Summersgill K, Hoffman H, Wang D, Klussmann J . Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer. 2003; 104(3):336-44. DOI: 10.1002/ijc.10960. View

Smith J, Lindsay L, Hoots B, Keys J, Franceschi S, Winer R . Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer. 2007; 121(3):621-32. DOI: 10.1002/ijc.22527. View

Parkin D . The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006; 118(12):3030-44. DOI: 10.1002/ijc.21731. View

Pintos J, Black M, Sadeghi N, Ghadirian P, Zeitouni A, Viscidi R . Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. Oral Oncol. 2007; 44(3):242-50. DOI: 10.1016/j.oraloncology.2007.02.005. View

Kreimer A, Clifford G, Boyle P, Franceschi S . Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev. 2005; 14(2):467-75. DOI: 10.1158/1055-9965.EPI-04-0551. View

Smith E, Ritchie J, Pawlita M, Rubenstein L, Haugen T, Turek L . Human papillomavirus seropositivity and risks of head and neck cancer. Int J Cancer. 2006; 120(4):825-32. DOI: 10.1002/ijc.22330. View

Coutlee F, Trottier A, Ghattas G, Leduc R, Toma E, Sanche G . Risk factors for oral human papillomavirus in adults infected and not infected with human immunodeficiency virus. Sex Transm Dis. 1997; 24(1):23-31. DOI: 10.1097/00007435-199701000-00006. View

10.

do Sacramento P, Babeto E, Colombo J, Ruback M, Bonilha J, Fernandes A . The prevalence of human papillomavirus in the oropharynx in healthy individuals in a Brazilian population. J Med Virol. 2006; 78(5):614-8. DOI: 10.1002/jmv.20583. View

11.

Buchinsky F, Carter J, Wipf G, Hughes J, Koutsky L, Galloway D . Comparison of oral fluid and serum ELISAs in the determination of IgG response to natural human papillomavirus infection in university women. J Clin Virol. 2005; 35(4):450-3. DOI: 10.1016/j.jcv.2005.09.014. View

12.

Giraldo P, Goncalves A, Pereira S, Barros-Mazon S, Gondo M, Witkin S . Human papillomavirus in the oral mucosa of women with genital human papillomavirus lesions. Eur J Obstet Gynecol Reprod Biol. 2005; 126(1):104-6. DOI: 10.1016/j.ejogrb.2005.09.009. View

13.

Hansson B, Rosenquist K, Antonsson A, Wennerberg J, Schildt E, Bladstrom A . Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol. 2005; 125(12):1337-44. DOI: 10.1080/00016480510043945. View

14.

Ragin C, Taioli E . Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer. 2007; 121(8):1813-20. DOI: 10.1002/ijc.22851. View

15.

Hafkamp H, Speel E, Haesevoets A, Bot F, Dinjens W, Ramaekers F . A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8. Int J Cancer. 2003; 107(3):394-400. DOI: 10.1002/ijc.11389. View

16.

Syrjanen S . HPV infections and tonsillar carcinoma. J Clin Pathol. 2004; 57(5):449-55. PMC: 1770289. DOI: 10.1136/jcp.2003.008656. View

17.

Snijders P, Cromme F, van den Brule A, Schrijnemakers H, Snow G, Meijer C . Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology. Int J Cancer. 1992; 51(6):845-50. DOI: 10.1002/ijc.2910510602. View

18.

Strome S, Savva A, Brissett A, Gostout B, Lewis J, Clayton A . Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations. Clin Cancer Res. 2002; 8(4):1093-100. View

19.

Rose B, Wilkins D, Li W, Tran N, Thompson C, Cossart Y . Human papillomavirus in the oral cavity of patients with and without renal transplantation. Transplantation. 2006; 82(4):570-3. DOI: 10.1097/01.tp.0000231706.79165.e5. View

20.

Marais D, Sampson C, Jeftha A, Dhaya D, Passmore J, Denny L . More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population. BMC Infect Dis. 2006; 6:95. PMC: 1524783. DOI: 10.1186/1471-2334-6-95. View