HPV Infections and Tonsillar Carcinoma

Overview

Journal J Clin Pathol

Specialty Pathology

Date 2004 Apr 29

PMID 15113849

Citations 74

Authors

S Syrjanen

Affiliations

Soon will be listed here.

Abstract

Since human papillomavirus (HPV) was first linked to laryngeal/oral carcinomas in 1983, several studies have confirmed its causal role in a subgroup of upper aerodigestive tract tumours. Of the non-genital cancers, tonsillar carcinomas (TCs) have the strongest association with HPV. By the end of 2002, 432 TCs had been analysed for HPV DNA. Overall detection rate was 51%, with HPV-16 being the most prevalent (84%). The original proposal that HPV-33 would be the most frequent HPV in TCs has not been confirmed, being present in only 4.6% of cases. HPV copy numbers are similar to those found in genital carcinomas (10-300 copies/cell), although HPV is mainly episomal in TC. The importance of this observation is unclear, although a role for subepithelial proliferative lymphatic tissue has been speculated. Patients with HPV-16 positive tumours have better overall and disease specific survival than HPV negative patients. They are also younger and the association with conventional risk factors-smoking and drinking-is less significant than in HPV negative patients. Thus, recent data suggest a distinct pattern for HPV-16 positive TCs.

Citing Articles

Direct Comparison of HPV16 Viral Genomic Integration, Copy Loss, and Structural Variants in Oropharyngeal and Uterine Cervical Cancers Reveal Distinct Relationships to E2 Disruption and Somatic Alteration.

Schrank T, Kim S, Rehmani H, Kothari A, Wu D, Yarbrough W Cancers (Basel). 2022; 14(18).

PMID: 36139648 PMC: 9496734. DOI: 10.3390/cancers14184488.

Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis.

Lang Kuhs K, Faden D, Chen L, Smith D, Pinheiro M, Wood C Ann Oncol. 2022; 33(6):638-648.

PMID: 35306154 PMC: 9350957. DOI: 10.1016/j.annonc.2022.03.005.

The Prevalence of High- and Low-Risk Types of HPV in Patients with Squamous Cell Carcinoma of the Head and Neck, Patients with Chronic Tonsillitis, and Healthy Individuals Living in Poland.

Strzelczyk J, Biernacki K, Gazdzicka J, Chelmecka E, Miskiewicz-Orczyk K, Zieba N Diagnostics (Basel). 2021; 11(12).

PMID: 34943415 PMC: 8699972. DOI: 10.3390/diagnostics11122180.

Incidence and risk factors of second primary cancer after the initial primary human papillomavirus related neoplasms.

Shen J, Zhou H, Liu J, Zhang Z, Fang W, Yang Y MedComm (2020). 2021; 1(3):400-409.

PMID: 34766131 PMC: 8491207. DOI: 10.1002/mco2.43.

Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy.

Bhat A, Yousuf P, Wani N, Rizwan A, Chauhan S, Siddiqi M Signal Transduct Target Ther. 2021; 6(1):12.

PMID: 33436555 PMC: 7804459. DOI: 10.1038/s41392-020-00419-w.

References

Brandwein M, Zeitlin J, Nuovo G, MacConnell P, Bodian C, Urken M . HPV detection using "hot start" polymerase chain reaction in patients with oral cancer: a clinicopathological study of 64 patients. Mod Pathol. 1994; 7(7):720-7. View

Schwartz S, Daling J, Doody D, Wipf G, Carter J, Madeleine M . Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst. 1998; 90(21):1626-36. DOI: 10.1093/jnci/90.21.1626. View

Frisch M, Goodman M . Human papillomavirus-associated carcinomas in Hawaii and the mainland U.S. Cancer. 2000; 88(6):1464-9. DOI: 10.1002/(sici)1097-0142(20000315)88:6<1464::aid-cncr26>3.0.co;2-o. View

Badaracco G, Venuti A, Bartolazzi A, Morello R, Marzetti F, Marcante M . Overexpression of p53 and bcl-2 proteins and the presence of HPV infection are independent events in head and neck cancer. J Oral Pathol Med. 2000; 29(4):173-9. DOI: 10.1034/j.1600-0714.2000.290405.x. View

Gillison M, Koch W, Capone R, Spafford M, Westra W, Wu L . Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000; 92(9):709-20. DOI: 10.1093/jnci/92.9.709. View

Badaracco G, Venuti A, Morello R, Muller A, Marcante M . Human papillomavirus in head and neck carcinomas: prevalence, physical status and relationship with clinical/pathological parameters. Anticancer Res. 2000; 20(2B):1301-5. View

Mellin H, Friesland S, Lewensohn R, Dalianis T, Munck-Wikland E . Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival. Int J Cancer. 2000; 89(3):300-4. View

Frisch M, Hjalgrim H, Jaeger A, Biggar R . Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Control. 2000; 11(6):489-95. DOI: 10.1023/a:1008918223334. View

Ishiji T, Kawase M, Honda M, Niimura M, Yoshimura E, Sata T . Distinctive distribution of human papillomavirus type 16 and type 20 DNA in the tonsillar and the skin carcinomas of a patient with epidermodysplasia verruciformis. Br J Dermatol. 2000; 143(5):1005-10. DOI: 10.1046/j.1365-2133.2000.03834.x. View

10.

Sanchez-Corona J, Montoya-Fuentes H, Bravo-Cuellar A, Morgan-Villela G, Troyo R . Human papillomavirus in tonsillar and nasopharyngeal carcinoma: isolation of HPV subtype 31. Ear Nose Throat J. 2001; 79(12):942-4. View

11.

Hemminki K, Dong C, Frisch M . Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands. Eur J Cancer Prev. 2001; 9(6):433-7. DOI: 10.1097/00008469-200012000-00010. View

12.

Mork J, Lie A, Glattre E, Hallmans G, Jellum E, Koskela P . Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 2001; 344(15):1125-31. DOI: 10.1056/NEJM200104123441503. View

13.

Watts K, Thompson C, Cossart Y, Rose B . Variable oncogene promoter activity of human papillomavirus type 16 cervical cancer isolates from Australia. J Clin Microbiol. 2001; 39(5):2009-14. PMC: 88072. DOI: 10.1128/JCM.39.5.2009-2014.2001. View

14.

Bagnardi V, Blangiardo M, La Vecchia C, Corrao G . A meta-analysis of alcohol drinking and cancer risk. Br J Cancer. 2001; 85(11):1700-5. PMC: 2363992. DOI: 10.1054/bjoc.2001.2140. View

15.

Klussmann J, Weissenborn S, Wieland U, Dries V, Kolligs J, Jungehuelsing M . Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer. 2001; 92(11):2875-84. DOI: 10.1002/1097-0142(20011201)92:11<2875::aid-cncr10130>3.0.co;2-7. View

16.

Peitsaro P, Johansson B, Syrjanen S . Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique. J Clin Microbiol. 2002; 40(3):886-91. PMC: 120275. DOI: 10.1128/JCM.40.3.886-891.2002. View

17.

Strome S, Savva A, Brissett A, Gostout B, Lewis J, Clayton A . Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations. Clin Cancer Res. 2002; 8(4):1093-100. View

18.

Peitsaro P, Hietanen S, Johansson B, Lakkala T, Syrjanen S . Single copy heterozygote integration of HPV 33 in chromosomal band 5p14 is found in an epithelial cell clone with selective growth advantage. Carcinogenesis. 2002; 23(6):1057-64. DOI: 10.1093/carcin/23.6.1057. View

19.

Syrjanen K . HPV infections and oesophageal cancer. J Clin Pathol. 2002; 55(10):721-8. PMC: 1769774. DOI: 10.1136/jcp.55.10.721. View

20.

Ringstrom E, Peters E, Hasegawa M, Posner M, Liu M, Kelsey K . Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res. 2002; 8(10):3187-92. View