Rapid Synthesis of 1,3,4,4-tetrasubstituted Beta-lactams from Methyleneaziridines Using a Four-component Reaction

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2008 Sep 24

PMID 18808185

Citations 4

Authors

Claire C A Cariou

Guy J Clarkson

Michael Shipman

Affiliations

Soon will be listed here.

Abstract

2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted beta-lactams in moderate to good yields (46-63%) via a "one-pot" process that brings together four components with the formation of three new intermolecular carbon-carbon bonds.

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