Calcification of Multipotent Prostate Tumor Endothelium

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2008 Sep 6

PMID 18772110

Citations 69

Authors

Andrew C Dudley

Zia A Khan

Shou-Ching Shih

Soo-Young Kang

Bernadette M M Zwaans

Joyce Bischoff

Michael Klagsbrun

Affiliations

Soon will be listed here.

Abstract

Solid tumors require new blood vessels for growth and metastasis, yet the biology of tumor-specific endothelial cells is poorly understood. We have isolated tumor endothelial cells from mice that spontaneously develop prostate tumors. Clonal populations of tumor endothelial cells expressed hematopoietic and mesenchymal stem cell markers and differentiated to form cartilage- and bone-like tissues. Chondrogenic differentiation was accompanied by an upregulation of cartilage-specific col2a1 and sox9, whereas osteocalcin and the metastasis marker osteopontin were upregulated during osteogenic differentiation. In human and mouse prostate tumors, ectopic vascular calcification was predominately luminal and colocalized with the endothelial marker CD31. Thus, prostate tumor endothelial cells are atypically multipotent and can undergo a mesenchymal-like transition.

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