Subversion of Complement by Hematophagous Parasites

Overview

Journal Dev Comp Immunol

Specialty Allergy & Immunology

Date 2008 Sep 3

PMID 18762211

Citations 33

Authors

Helene Schroeder

Patrick J Skelly

Peter F Zipfel

Bertrand Losson

Alain Vanderplasschen

Affiliations

Soon will be listed here.

Abstract

The complement system is a crucial part of innate and adaptive immunity which exerts a significant evolutionary pressure on pathogens. It has selected for those pathogens, mainly microorganisms but also parasites, that have evolved countermeasures. The characterization of how pathogens evade complement attack is a rapidly developing field of current research. In recent years, multiple complement evasion strategies have been characterized. In this review, we focus on complement escape mechanisms expressed by hematophagous parasites, a heterogeneous group of metazoan parasites that share the property of ingesting the whole blood of their host. Complement inhibition is crucial for parasite survival within the host tissue or to facilitate blood feeding. Finally, complement inhibition by hematophagous parasites may also contribute to their success as pathogen vectors.

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