Dissociation of Frontal and Medial Temporal Lobe Activity in Maintenance and Binding of Sequentially Presented Paired Associates

Overview

Journal J Cogn Neurosci

Specialty Neurology

Date 2008 Aug 30

PMID 18752401

Citations 17

Authors

Jena B Hales

Sarah L Israel

Nicole C Swann

James B Brewer

Affiliations

Soon will be listed here.

Abstract

Substructures of the prefrontal cortex (PFC) and the medial-temporal lobe are critical for associating objects presented over time. Previous studies showing frontal and medial-temporal involvement in associative encoding have not addressed the response specificity of these regions to different aspects of the task, which include instructions to associate and binding of stimuli. This study used a novel paradigm to temporally separate these two components of the task by sequential presentation of individual images with or without associative instruction; fMRI was used to investigate the temporal involvement of the PFC and the parahippocampal cortex in encoding each component. Although both regions showed an enhanced response to the second stimulus of a pair, only the PFC had increased activation during the delay preceding a stimulus when associative instruction was given. These findings present new evidence that prefrontal and medial-temporal regions provide distinct temporal contributions during associative memory formation.

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References

Blumenfeld R, Ranganath C . Dorsolateral prefrontal cortex promotes long-term memory formation through its role in working memory organization. J Neurosci. 2006; 26(3):916-25. PMC: 6675388. DOI: 10.1523/JNEUROSCI.2353-05.2006. View

Vanderhasselt M, De Raedt R, Baeken C, Leyman L, DHaenen H . The influence of rTMS over the right dorsolateral prefrontal cortex on intentional set switching. Exp Brain Res. 2006; 172(4):561-5. DOI: 10.1007/s00221-006-0540-5. View

Prince S, Daselaar S, Cabeza R . Neural correlates of relational memory: successful encoding and retrieval of semantic and perceptual associations. J Neurosci. 2005; 25(5):1203-10. PMC: 6725951. DOI: 10.1523/JNEUROSCI.2540-04.2005. View

Dale A, Buckner R . Selective averaging of rapidly presented individual trials using fMRI. Hum Brain Mapp. 2010; 5(5):329-40. DOI: 10.1002/(SICI)1097-0193(1997)5:5<329::AID-HBM1>3.0.CO;2-5. View

Rossion B, Pourtois G . Revisiting Snodgrass and Vanderwart's object pictorial set: the role of surface detail in basic-level object recognition. Perception. 2004; 33(2):217-36. DOI: 10.1068/p5117. View

Fuster J, Bodner M, Kroger J . Cross-modal and cross-temporal association in neurons of frontal cortex. Nature. 2000; 405(6784):347-51. DOI: 10.1038/35012613. View

Vidyasagar T, Salzmann E, CREUTZFELDT O . Unit activity in the hippocampus and the parahippocampal temporobasal association cortex related to memory and complex behaviour in the awake monkey. Brain Res. 1991; 544(2):269-78. DOI: 10.1016/0006-8993(91)90064-3. View

Pihlajamaki M, Tanila H, Hanninen T, Kononen M, Mikkonen M, Jalkanen V . Encoding of novel picture pairs activates the perirhinal cortex: an fMRI study. Hippocampus. 2003; 13(1):67-80. DOI: 10.1002/hipo.10049. View

Dickerson B, Miller S, Greve D, Dale A, Albert M, Schacter D . Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study. Hippocampus. 2007; 17(11):1060-70. PMC: 2739881. DOI: 10.1002/hipo.20338. View

10.

Eichenbaum H, Yonelinas A, Ranganath C . The medial temporal lobe and recognition memory. Annu Rev Neurosci. 2007; 30:123-52. PMC: 2064941. DOI: 10.1146/annurev.neuro.30.051606.094328. View

11.

Young B, Otto T, Fox G, Eichenbaum H . Memory representation within the parahippocampal region. J Neurosci. 1997; 17(13):5183-95. PMC: 6573311. View

12.

Tendolkar I, Arnold J, Petersson K, Weis S, Brockhaus-Dumke A, van Eijndhoven P . Probing the neural correlates of associative memory formation: a parametrically analyzed event-related functional MRI study. Brain Res. 2007; 1142:159-68. DOI: 10.1016/j.brainres.2007.01.040. View

13.

Law J, Flanery M, Wirth S, Yanike M, Smith A, Frank L . Functional magnetic resonance imaging activity during the gradual acquisition and expression of paired-associate memory. J Neurosci. 2005; 25(24):5720-9. PMC: 6724878. DOI: 10.1523/JNEUROSCI.4935-04.2005. View

14.

Henke K, Buck A, Weber B, Wieser H . Human hippocampus establishes associations in memory. Hippocampus. 1997; 7(3):249-56. DOI: 10.1002/(SICI)1098-1063(1997)7:3<249::AID-HIPO1>3.0.CO;2-G. View

15.

Cahusac P, Miyashita Y, Rolls E . Responses of hippocampal formation neurons in the monkey related to delayed spatial response and object-place memory tasks. Behav Brain Res. 1989; 33(3):229-40. DOI: 10.1016/s0166-4328(89)80118-4. View

16.

Habib R, Nyberg L, Tulving E . Hemispheric asymmetries of memory: the HERA model revisited. Trends Cogn Sci. 2003; 7(6):241-245. DOI: 10.1016/s1364-6613(03)00110-4. View

17.

Kirwan C, Stark C . Medial temporal lobe activation during encoding and retrieval of novel face-name pairs. Hippocampus. 2004; 14(7):919-30. PMC: 2704554. DOI: 10.1002/hipo.20014. View

18.

Takahashi E, Ohki K, Kim D . Diffusion tensor studies dissociated two fronto-temporal pathways in the human memory system. Neuroimage. 2006; 34(2):827-38. PMC: 1933506. DOI: 10.1016/j.neuroimage.2006.10.009. View

19.

Daselaar S, Rice H, Greenberg D, Cabeza R, LaBar K, Rubin D . The spatiotemporal dynamics of autobiographical memory: neural correlates of recall, emotional intensity, and reliving. Cereb Cortex. 2007; 18(1):217-29. DOI: 10.1093/cercor/bhm048. View

20.

Davachi L, Mitchell J, Wagner A . Multiple routes to memory: distinct medial temporal lobe processes build item and source memories. Proc Natl Acad Sci U S A. 2003; 100(4):2157-62. PMC: 149975. DOI: 10.1073/pnas.0337195100. View