Diffusion Tensor MR Imaging in Chronic Spinal Cord Injury

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2008 Aug 23

PMID 18719029

Citations 47

Authors

B M Ellingson

J L Ulmer

S N Kurpad

B D Schmit

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Diffusion tensor MR imaging is emerging as an important tool for displaying anatomic changes in the brain after injury or disease but has been less widely applied to disorders of the spinal cord. The aim of this study was to characterize the diffusion properties of the entire human spinal cord in vivo during the chronic stages of spinal cord injury (SCI). These data provide insight into the structural changes that occur as a result of long-term recovery from spinal trauma.

Materials And Methods: Thirteen neurologically intact subjects and 10 subjects with chronic SCI (>4 years postinjury) were enrolled in this study. A single-shot twice-refocused spin-echo diffusion-weighted echo-planar imaging pulse sequence was used to obtain axial images throughout the entire spinal cord (C1-L1) in <60 minutes.

Results: Despite heterogeneity in SCI lesion severity and location, diffusion characteristics of the chronic lesion were significantly elevated compared with those of uninjured controls. Fractional anisotropy was significantly lower at the chronic lesion and appeared dependent on the completeness of the injury. Conversely, mean diffusivity measurements in the upper cervical spinal cord in subjects with SCI were significantly lower than those in controls. These trends suggest that the entire neuraxis may be affected by long-term recovery from spinal trauma.

Conclusion: These results suggest that diffusion tensor imaging may be useful in the assessment of SCI recovery.

Citing Articles

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Changes in respiratory structure and function after traumatic cervical spinal cord injury: observations from spinal cord and brain.

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Role of diffusion tensor imaging and tractography in spinal cord injury.

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References

Reese T, Heid O, Weisskoff R, Wedeen V . Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn Reson Med. 2003; 49(1):177-82. DOI: 10.1002/mrm.10308. View

Piepmeier J, Jenkins N . Late neurological changes following traumatic spinal cord injury. J Neurosurg. 1988; 69(3):399-402. DOI: 10.3171/jns.1988.69.3.0399. View

Nightingale E, Raymond J, Middleton J, Crosbie J, Davis G . Benefits of FES gait in a spinal cord injured population. Spinal Cord. 2007; 45(10):646-57. DOI: 10.1038/sj.sc.3102101. View

Schwartz E, Shumsky J, Wehrli S, Tessler A, Murray M, Hackney D . Ex vivo MR determined apparent diffusion coefficients correlate with motor recovery mediated by intraspinal transplants of fibroblasts genetically modified to express BDNF. Exp Neurol. 2003; 182(1):49-63. DOI: 10.1016/s0014-4886(03)00036-0. View

Guan Koay C, Carew J, Alexander A, Basser P, Meyerand M . Investigation of anomalous estimates of tensor-derived quantities in diffusion tensor imaging. Magn Reson Med. 2006; 55(4):930-6. DOI: 10.1002/mrm.20832. View

Ellingson B, Ulmer J, Schmit B . Gray and white matter delineation in the human spinal cord using diffusion tensor imaging and fuzzy logic. Acad Radiol. 2007; 14(7):847-58. DOI: 10.1016/j.acra.2007.04.006. View

Marshall L, Knowlton S, Garfin S, Klauber M, Eisenberg H, Kopaniky D . Deterioration following spinal cord injury. A multicenter study. J Neurosurg. 1987; 66(3):400-4. DOI: 10.3171/jns.1987.66.3.0400. View

Demir A, Ries M, Moonen C, Vital J, Dehais J, Arne P . Diffusion-weighted MR imaging with apparent diffusion coefficient and apparent diffusion tensor maps in cervical spondylotic myelopathy. Radiology. 2003; 229(1):37-43. DOI: 10.1148/radiol.2291020658. View

Bammer R, Stollberger R, Augustin M, Simbrunner J, Offenbacher H, Kooijman H . Diffusion-weighted imaging with navigated interleaved echo-planar imaging and a conventional gradient system. Radiology. 1999; 211(3):799-806. DOI: 10.1148/radiology.211.3.r99jn15799. View

10.

Kaufman L, Kramer D, Crooks L, Ortendahl D . Measuring signal-to-noise ratios in MR imaging. Radiology. 1989; 173(1):265-7. DOI: 10.1148/radiology.173.1.2781018. View

11.

Harrison B, McDonald W . Remyelination after transient experimental compression of the spinal cord. Ann Neurol. 1977; 1(6):542-51. DOI: 10.1002/ana.410010606. View

12.

Poonawalla A, Zhou X . Analytical error propagation in diffusion anisotropy calculations. J Magn Reson Imaging. 2004; 19(4):489-98. DOI: 10.1002/jmri.20020. View

13.

Mamata H, Jolesz F, Maier S . Apparent diffusion coefficient and fractional anisotropy in spinal cord: age and cervical spondylosis-related changes. J Magn Reson Imaging. 2005; 22(1):38-43. DOI: 10.1002/jmri.20357. View

14.

Sagiuchi T, Tachibana S, Endo M, Hayakawa K . Diffusion-weighted MRI of the cervical cord in acute spinal cord injury with type II odontoid fracture. J Comput Assist Tomogr. 2002; 26(4):654-6. DOI: 10.1097/00004728-200207000-00032. View

15.

Nagayoshi K, Kimura S, Ochi M, Hayashi K, Okimoto T, Wakebe T . Diffusion-weighted echo planar imaging of the normal human cervical spinal cord. J Comput Assist Tomogr. 2000; 24(3):482-5. DOI: 10.1097/00004728-200005000-00023. View

16.

Sagiuchi T, Iida H, Tachibana S, Kusumi M, Kan S, Fujii K . Case report: diffusion-weighted MRI in anterior spinal artery stroke of the cervical spinal cord. J Comput Assist Tomogr. 2003; 27(3):410-4. DOI: 10.1097/00004728-200305000-00018. View

17.

Potter K, Saifuddin A . Pictorial review: MRI of chronic spinal cord injury. Br J Radiol. 2003; 76(905):347-52. DOI: 10.1259/bjr/11881183. View

18.

DeBoy C, Zhang J, Dike S, Shats I, Jones M, Reich D . High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord. Brain. 2007; 130(Pt 8):2199-210. DOI: 10.1093/brain/awm122. View

19.

Holder C, Muthupillai R, Mukundan Jr S, Eastwood J, Hudgins P . Diffusion-weighted MR imaging of the normal human spinal cord in vivo. AJNR Am J Neuroradiol. 2000; 21(10):1799-806. PMC: 7974290. View

20.

Jones D, Horsfield M, Simmons A . Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med. 1999; 42(3):515-25. View