Generation of Molecular Diversity Using a Complexity-generating MCR-platform Towards Triazinane Diones

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2008 Aug 14

PMID 18698475

Citations 4

Authors

Bas Groenendaal

Eelco Ruijter

Frans J J de Kanter

Martin Lutz

Anthony L Spek

Romano V A Orru

Affiliations

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Abstract

Triazinane diones, readily generated by a recently reported multicomponent reaction, can be easily alkylated with various alkyl halides, allowing a wide variety of complexity-generating secondary reactions. Because of the high variability of the initial multicomponent reactions and the multiple possibilities for participation of substituents in the secondary reactions, a highly diverse set of complex products was obtained in short and efficient reaction sequences.

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