Effects of in Vitro Maturation on Gene Expression in Rhesus Monkey Oocytes

Overview

Journal Physiol Genomics

Publisher American Physiological Society

Specialties Genetics
Molecular Biology

Date 2008 Aug 14

PMID 18697858

Citations 21

Authors

Young S Lee

Keith E Latham

Catherine A VandeVoort

Affiliations

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Abstract

In vitro oocyte maturation (IVM) holds great promise as a tool for enhancing clinical treatment of infertility, enhancing availability of nonhuman primates for development of disease models, and facilitating endangered species preservation. However, IVM outcomes have remained significantly below the success rates obtained with in vivo matured (VVM) oocytes from humans and nonhuman primates. A cDNA array-based analysis is presented, comparing the transcriptomes of VVM oocytes with IVM oocytes. We observe a small set of just 59 mRNAs that are differentially expressed between the two cell types. These mRNAs are related to cellular homeostasis, cell-cell interactions including growth factor and hormone stimulation and cell adhesion, and other functions such as mRNA stability and translation. Additionally, we observe in IVM oocytes overexpression of PLAGL1 and MEST, two maternally imprinted genes, indicating a possible interruption or loss of correct epigenetic programming. These results indicate that, under certain IVM conditions, oocytes that are molecularly highly similar to VVM oocytes can be obtained; however, the interruption of normal oocyte-somatic cell interactions during the final hours of oocyte maturation may preclude the establishment of full developmental competence.

Citing Articles

Dysregulation of bisphosphoglycerate mutase during in vitro maturation of oocytes.

Lim M, Brown H, Rose R, Thompson J, Dunning K J Assist Reprod Genet. 2021; 38(6):1363-1372.

PMID: 34052998 PMC: 8266955. DOI: 10.1007/s10815-021-02230-0.

Genotypic divergence in mouse oocyte transcriptomes: possible pathways to hybrid vigor impacting fertility and embryogenesis.

Severance A, Midic U, Latham K Physiol Genomics. 2019; 52(2):96-109.

PMID: 31869285 PMC: 7052567. DOI: 10.1152/physiolgenomics.00078.2019.

Differential gene expression between and maturation: a comparative study with bovine oocytes derived from the same donor pool.

Camargo L, Munk M, Sales J, Wohlres-Viana S, Quintao C, Viana J JBRA Assist Reprod. 2019; 23(1):7-14.

PMID: 30614236 PMC: 6364282. DOI: 10.5935/1518-0557.20180084.

Disruptions in follicle cell functions in the ovaries of rhesus monkeys during summer.

VandeVoort C, Mtango N, Midic U, Latham K Physiol Genomics. 2015; 47(4):102-12.

PMID: 25586978 PMC: 4385968. DOI: 10.1152/physiolgenomics.00092.2014.

RNA-Seq profiling of single bovine oocyte transcript abundance and its modulation by cytoplasmic polyadenylation.

Reyes J, Chitwood J, Ross P Mol Reprod Dev. 2015; 82(2):103-14.

PMID: 25560149 PMC: 4651626. DOI: 10.1002/mrd.22445.

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