» Articles » PMID: 18697666

Fitting Computational Models to FMRI

Overview
Publisher Springer
Specialty Social Sciences
Date 2008 Aug 14
PMID 18697666
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Many computational models in psychology predict how neural activation in specific brain regions should change during certain cognitive tasks. The emergence of fMRI as a research tool provides an ideal vehicle totest these predictions. Before such tests are possible, however, significant methodological problems must be solved. These problems include transforming the neural activations predicted by the model into predicted BOLD responses, identifying the voxels within each region of interest against which to test the model, and comparing the observed and predicted BOLD responses in each of these regions. In the present article, methods are described for solving each of these problems.

Citing Articles

Interpretation of individual differences in computational neuroscience using a latent input approach.

Schaaf J, Miletic S, van Duijvenvoorde A, Huizenga H Dev Cogn Neurosci. 2025; 72:101512.

PMID: 39854872 PMC: 11804603. DOI: 10.1016/j.dcn.2025.101512.


How do neural processes give rise to cognition? Simultaneously predicting brain and behavior with a dynamic model of visual working memory.

Buss A, Magnotta V, Penny W, Schoner G, Huppert T, Spencer J Psychol Rev. 2021; 128(2):362-395.

PMID: 33570976 PMC: 11327926. DOI: 10.1037/rev0000264.


Computations Underlying Social Hierarchy Learning: Distinct Neural Mechanisms for Updating and Representing Self-Relevant Information.

Kumaran D, Banino A, Blundell C, Hassabis D, Dayan P Neuron. 2016; 92(5):1135-1147.

PMID: 27930904 PMC: 5158095. DOI: 10.1016/j.neuron.2016.10.052.


Reward salience and risk aversion underlie differential ACC activity in substance dependence.

Alexander W, Fukunaga R, Finn P, Brown J Neuroimage Clin. 2015; 8:59-71.

PMID: 26106528 PMC: 4473292. DOI: 10.1016/j.nicl.2015.02.025.


The emergent executive: a dynamic field theory of the development of executive function.

Buss A, Spencer J Monogr Soc Res Child Dev. 2014; 79(2):vii, 1-103.

PMID: 24818836 PMC: 4426851. DOI: 10.1002/mono.12096.


References
1.
Zarahn E, Aguirre G, DEsposito M . A trial-based experimental design for fMRI. Neuroimage. 1997; 6(2):122-38. DOI: 10.1006/nimg.1997.0279. View

2.
OReilly R . Biologically based computational models of high-level cognition. Science. 2006; 314(5796):91-4. DOI: 10.1126/science.1127242. View

3.
Ashby F, Ennis J, Spiering B . A neurobiological theory of automaticity in perceptual categorization. Psychol Rev. 2007; 114(3):632-56. DOI: 10.1037/0033-295X.114.3.632. View

4.
Buxton R, Wong E, Frank L . Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med. 1998; 39(6):855-64. DOI: 10.1002/mrm.1910390602. View

5.
Boynton G, Engel S, Glover G, Heeger D . Linear systems analysis of functional magnetic resonance imaging in human V1. J Neurosci. 1996; 16(13):4207-21. PMC: 6579007. View