» Articles » PMID: 18679436

The Multiple Lives of NMD Factors: Balancing Roles in Gene and Genome Regulation

Overview
Journal Nat Rev Genet
Specialty Genetics
Date 2008 Aug 6
PMID 18679436
Citations 192
Authors
Affiliations
Soon will be listed here.
Abstract

Nonsense-mediated mRNA decay (NMD) largely functions to ensure the quality of gene expression. However, NMD is also crucial to regulating appropriate expression levels for certain genes and for maintaining genome stability. Furthermore, just as NMD serves cells in multiple ways, so do its constituent proteins. Recent studies have clarified that UPF and SMG proteins, which were originally discovered to function in NMD, also have roles in other pathways, including specialized pathways of mRNA decay, DNA synthesis and cell-cycle progression, and the maintenance of telomeres. These findings suggest a delicate balance of metabolic events - some not obviously related to NMD - that can be influenced by the cellular abundance, location and activity of NMD factors and their binding partners.

Citing Articles

Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish.

Lai S, Shiraishi H, Sebastian W, Shimizu N, Umeda R, Ikeuchi M Commun Biol. 2024; 7(1):654.

PMID: 38806677 PMC: 11133409. DOI: 10.1038/s42003-024-06356-6.


Structural Motifs at the Telomeres and Their Role in Regulatory Pathways.

Alanazi A, Parkinson G, Haider S Biochemistry. 2024; 63(7):827-842.

PMID: 38481135 PMC: 10993422. DOI: 10.1021/acs.biochem.4c00023.


CAG repeat expansion in the Huntington's disease gene shapes linear and circular RNAs biogenesis.

Ayyildiz D, Bergonzoni G, Monziani A, Tripathi T, Doring J, Kerschbamer E PLoS Genet. 2023; 19(10):e1010988.

PMID: 37831730 PMC: 10617732. DOI: 10.1371/journal.pgen.1010988.


FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

Cho S, Chun Y, He L, Ramirez C, Ganesh K, Jeong K Mol Cell. 2023; 83(16):3010-3026.e8.

PMID: 37595559 PMC: 10494788. DOI: 10.1016/j.molcel.2023.07.017.


Two- and three-dimensional sonographic findings of harlequin ichthyosis: case report and literature review.

Liu Z, Jing C An Bras Dermatol. 2023; 98(6):806-813.

PMID: 37355352 PMC: 10589490. DOI: 10.1016/j.abd.2022.09.013.


References
1.
Kawano T, Kataoka N, Dreyfuss G, Sakamoto H . Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans. Mech Dev. 2004; 121(1):27-35. DOI: 10.1016/j.mod.2003.11.003. View

2.
Meaux S, van Hoof A, Baker K . Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail. Mol Cell. 2008; 29(1):134-40. PMC: 2241659. DOI: 10.1016/j.molcel.2007.10.031. View

3.
Tange T, Shibuya T, Jurica M, Moore M . Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA. 2005; 11(12):1869-83. PMC: 1370875. DOI: 10.1261/rna.2155905. View

4.
Lejeune F, Ishigaki Y, Li X, Maquat L . The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J. 2002; 21(13):3536-45. PMC: 126094. DOI: 10.1093/emboj/cdf345. View

5.
Denning G, Jamieson L, Maquat L, Thompson E, Fields A . Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem. 2001; 276(25):22709-14. DOI: 10.1074/jbc.C100144200. View