The Role of Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-activating Polypeptide in the Neural Pathways Controlling the Lower Urinary Tract

Overview

Journal J Mol Neurosci

Specialties Molecular Biology
Neurology

Date 2008 Aug 5

PMID 18677446

Citations 21

Authors

Mitsuharu Yoshiyama

William C de Groat

Affiliations

Soon will be listed here.

Abstract

Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are expressed in the neural pathways regulating the lower urinary tract. VIP-immunoreactivity (IR) is present in afferent and autonomic efferent neurons innervating the bladder and urethra, whereas PACAP-IR is present primarily in afferent neurons. Exogenously applied VIP relaxes bladder and urethral smooth muscle and excites parasympathetic neurons in bladder ganglia. PACAP relaxes bladder and urethral smooth muscle in some species (pig) but excites the smooth muscle in other species (mouse). Intrathecal administration of VIP in cats with an intact spinal cord suppresses reflex bladder activity, but intrathecal administration of VIP or PACAP in rats enhances bladder activity and suppresses urethral sphincter activity. PACAP has presynaptic facilitatory effects and direct excitatory effects on lumbosacral parasympathetic preganglionic neurons. Chronic spinal cord transection produces an expansion of VIP-IR (cats) and PACAP-IR (rats) in primary afferent axons in the lumbosacral spinal cord and unmasks spinal excitatory effects of VIP on bladder reflexes in cats. Intrathecal administration of PACAP6-38, a PAC1 receptor antagonist, reduces bladder hyperactivity in chronic spinal-cord-injured rats. These observations raise the possibility that VIP or PACAP have a role in the control of normal or abnormal voiding.

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References

Morgan C, Ohara P, Scott D . Vasoactive intestinal polypeptide in sacral primary sensory pathways in the cat. J Comp Neurol. 1999; 407(3):381-94. DOI: 10.1002/(sici)1096-9861(19990510)407:3<381::aid-cne6>3.0.co;2-j. View

Kruse M, Noto H, Roppolo J, de Groat W . Pontine control of the urinary bladder and external urethral sphincter in the rat. Brain Res. 1990; 532(1-2):182-90. DOI: 10.1016/0006-8993(90)91758-9. View

Alm P, Alumets J, Hakanson R, Owman O, SJOBERG N, Sundler F . Origin and distribution of VIP (vasoactive intestinal polypeptide)-nerves in the genito-urinary tract. Cell Tissue Res. 1980; 205(3):337-47. DOI: 10.1007/BF00232276. View

Crowe R, Vale J, Trott K, Soediono P, Robson T, Burnstock G . Radiation-induced changes in neuropeptides in the rat urinary bladder. J Urol. 1996; 156(6):2062-6. View

Zvarova K, Dunleavy J, Vizzard M . Changes in pituitary adenylate cyclase activating polypeptide expression in urinary bladder pathways after spinal cord injury. Exp Neurol. 2005; 192(1):46-59. DOI: 10.1016/j.expneurol.2004.10.017. View

Cheng C, de Groat W . The role of capsaicin-sensitive afferent fibers in the lower urinary tract dysfunction induced by chronic spinal cord injury in rats. Exp Neurol. 2004; 187(2):445-54. DOI: 10.1016/j.expneurol.2004.02.014. View

Milner P, Crowe R, Burnstock G, Light J . Neuropeptide Y- and vasoactive intestinal polypeptide-containing nerves in the intrinsic external urethral sphincter in the areflexic bladder compared to detrusor-sphincter dyssynergia in patients with spinal cord injury. J Urol. 1987; 138(4):888-92. DOI: 10.1016/s0022-5347(17)43409-4. View

Callahan S, Creed K . Non-cholinergic neurotransmission and the effects of peptides on the urinary bladder of guinea-pigs and rabbits. J Physiol. 1986; 374:103-15. PMC: 1182709. DOI: 10.1113/jphysiol.1986.sp016068. View

Noto H, Roppolo J, Steers W, de Groat W . Electrophysiological analysis of the ascending and descending components of the micturition reflex pathway in the rat. Brain Res. 1991; 549(1):95-105. DOI: 10.1016/0006-8993(91)90604-t. View

10.

de Groat W . Nervous control of the urinary bladder of the cat. Brain Res. 1975; 87(2-3):201-11. DOI: 10.1016/0006-8993(75)90417-5. View

11.

Zhou Y, Ling E . Colocalization of nitric oxide synthase and some neurotransmitters in the intramural ganglia of the guinea pig urinary bladder. J Comp Neurol. 1998; 394(4):496-505. View

12.

Werkstrom V, Persson K, Andersson K . NANC transmitters in the female pig urethra--localization and modulation of release via alpha 2-adrenoceptors and potassium channels. Br J Pharmacol. 1997; 121(8):1605-12. PMC: 1564865. DOI: 10.1038/sj.bjp.0701308. View

13.

Gibson S, Polak J, Anand P, Blank M, Morrison J, Kelly J . The distribution and origin of VIP in the spinal cord of six mammalian species. Peptides. 1984; 5(2):201-7. DOI: 10.1016/0196-9781(84)90207-9. View

14.

Hernandez M, Barahona M, Recio P, Benedito S, Martinez A, Rivera L . Neuronal and smooth muscle receptors involved in the PACAP- and VIP-induced relaxations of the pig urinary bladder neck. Br J Pharmacol. 2006; 149(1):100-9. PMC: 1629402. DOI: 10.1038/sj.bjp.0706832. View

15.

Andersson K, Mattiasson A, Sjogren C . Electrically induced relaxation of the noradrenaline contracted isolated urethra from rabbit and man. J Urol. 1983; 129(1):210-4. DOI: 10.1016/s0022-5347(17)51986-2. View

16.

Sjogren C, Andersson K, Mattiasson A . Effects of vasoactive intestinal polypeptide on isolated urethral and urinary bladder smooth muscle from rabbit and man. J Urol. 1985; 133(1):136-40. DOI: 10.1016/s0022-5347(17)48822-7. View

17.

Laburthe M, Couvineau A, Marie J . VPAC receptors for VIP and PACAP. Recept Channels. 2003; 8(3-4):137-53. View

18.

Yoshimura N, Bennett N, Hayashi Y, Ogawa T, Nishizawa O, Chancellor M . Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats. J Neurosci. 2006; 26(42):10847-55. PMC: 6674760. DOI: 10.1523/JNEUROSCI.3023-06.2006. View

19.

Sie J, Blok B, de Weerd H, Holstege G . Ultrastructural evidence for direct projections from the pontine micturition center to glycine-immunoreactive neurons in the sacral dorsal gray commissure in the cat. J Comp Neurol. 2001; 429(4):631-7. DOI: 10.1002/1096-9861(20010122)429:4<631::aid-cne9>3.0.co;2-m. View

20.

Kawatani M, TAKESHIGE C, de Groat W . Central distribution of afferent pathways from the uterus of the cat. J Comp Neurol. 1990; 302(2):294-304. DOI: 10.1002/cne.903020208. View