Integrating Biological Data--the Distributed Annotation System

Overview

Journal BMC Bioinformatics

Publisher Biomed Central

Specialty Biology

Date 2008 Aug 5

PMID 18673527

Citations 55

Authors

Andrew M Jenkinson

Mario Albrecht

Ewan Birney

Hagen Blankenburg

Thomas Down

Robert D Finn

Henning Hermjakob

Tim J P Hubbard

Rafael C Jimenez

Philip Jones

Andreas Kahari

Eugene Kulesha

Jose R Macias

Gabrielle A Reeves

Andreas Prlic

Affiliations

Soon will be listed here.

Abstract

Background: The Distributed Annotation System (DAS) is a widely adopted protocol for dynamically integrating a wide range of biological data from geographically diverse sources. DAS continues to expand its applicability and evolve in response to new challenges facing integrative bioinformatics.

Results: Here we describe the various infrastructure components of DAS and present a new extended version of the DAS specification. Version 1.53E incorporates several recent developments, including its extension to serve new data types and an ontology for protein features.

Conclusion: Our extensions to the DAS protocol have facilitated the integration of new data types, and our improvements to the existing DAS infrastructure have addressed recent challenges. The steadily increasing numbers of available data sources demonstrates further adoption of the DAS protocol.

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