Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-resistant Beta-lactamase from Klebsiella Pneumoniae

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2008 Jul 30

PMID 18663019

Citations 15

Authors

Veronique Dubois

Laurent Poirel

Francois Demarthe

Corinne Arpin

Laure Coulange

Luciene A R Minarini

Marie-Christine Bezian

Patrice Nordmann

Claudine Quentin

Affiliations

Soon will be listed here.

Abstract

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

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