Validation of the Simplified Chinese Version of EORTC QLQ-C30 from the Measurements of Five Types of Inpatients with Cancer

Overview

Journal Ann Oncol

Publisher Elsevier

Specialty Oncology

Date 2008 Jul 26

PMID 18653703

Citations 58

Authors

C Wan

Q Meng

Z Yang

X Tu

C Feng

X Tang

C Zhang

Affiliations

Soon will be listed here.

Abstract

Background: European Organization for Research and Treatment quality of life (QOL) questionnaire (QLQ-C30) has been used frequently and many language versions have been developed, including the simplified Chinese version. It is important to study psychometric properties of the simplified Chinese version from the clinical standpoint.

Patients And Methods: The simplified Chinese version of the QLQ-C30 was used in a longitudinal study of 600 patients with five types of cancer: lung, breast, head and neck, colorectal, and stomach. The psychometric properties of the scale were evaluated by indicators of validity and reliability coefficients such as Cronbach's alpha and Pearson's correlation coefficient r, standardized response mean (SRM), correlational analysis, t-tests, and structural equation models.

Results: Correlation and structural equation model analyses confirmed good construct validity with root mean square error of approximation 0.054, standardized root mean square residual 0.037, non-normed fit index 0.972, and comparative fit index 0.980. The alpha coefficients for all domains are >0.7 except for cognitive functioning (0.49). The test-retest reliability coefficients for most domains are >0.80 except for appetite loss (0.77) and diarrhea (0.75). The QOL score changes after treatments were of statistical significance with higher or moderate SRM in most domains.

Conclusion: The simplified Chinese version of QLQ-C30 has good validity, reliability, and responsiveness and can be used to measure QOL for Chinese cancer patients.

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References

van der Steeg A, de Vries J, Roukema J . Quality of life and health status in breast carcinoma. Eur J Surg Oncol. 2004; 30(10):1051-7. DOI: 10.1016/j.ejso.2004.07.003. View

McLachlan S, Devins G, Goodwin P . Validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) as a measure of psychosocial function in breast cancer patients. Eur J Cancer. 1998; 34(4):510-7. DOI: 10.1016/s0959-8049(97)10076-4. View

Yun Y, Park Y, Lee E, Bang S, Heo D, Park S . Validation of the Korean version of the EORTC QLQ-C30. Qual Life Res. 2004; 13(4):863-8. DOI: 10.1023/B:QURE.0000021692.81214.70. View

Wan C, Yang Z, Meng Q, Feng C, Wang H, Tang X . Development and validation of the general module of the system of quality of life instruments for cancer patients. Int J Cancer. 2007; 122(1):190-6. DOI: 10.1002/ijc.23036. View

Norman G, Stratford P, Regehr G . Methodological problems in the retrospective computation of responsiveness to change: the lesson of Cronbach. J Clin Epidemiol. 1997; 50(8):869-79. DOI: 10.1016/s0895-4356(97)00097-8. View

Kyriaki M, Eleni T, Efi P, Ourania K, Vassilios S, Lambros V . The EORTC core quality of life questionnaire (QLQ-C30, version 3.0) in terminally ill cancer patients under palliative care: validity and reliability in a Hellenic sample. Int J Cancer. 2001; 94(1):135-9. DOI: 10.1002/ijc.1439. View

Cella D, Tulsky D, Gray G, Sarafian B, Linn E, Bonomi A . The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol. 1993; 11(3):570-9. DOI: 10.1200/JCO.1993.11.3.570. View

Chie W, Yang C, Hsu C, Yang P . Quality of life of lung cancer patients: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and QLQ-LC13. Qual Life Res. 2004; 13(1):257-62. DOI: 10.1023/B:QURE.0000015295.74812.06. View

Terwee C, Dekker F, Wiersinga W, Prummel M, Bossuyt P . On assessing responsiveness of health-related quality of life instruments: guidelines for instrument evaluation. Qual Life Res. 2003; 12(4):349-62. DOI: 10.1023/a:1023499322593. View

10.

Aaronson N, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez N . The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993; 85(5):365-76. DOI: 10.1093/jnci/85.5.365. View

11.

Silpakit C, Sirilerttrakul S, Jirajarus M, Sirisinha T, Sirachainan E, Ratanatharathorn V . The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): validation study of the Thai version. Qual Life Res. 2006; 15(1):167-72. DOI: 10.1007/s11136-005-0449-7. View

12.

Luo N, Fones C, Lim S, Xie F, Thumboo J, Li S . The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-c30): validation of English version in Singapore. Qual Life Res. 2005; 14(4):1181-6. DOI: 10.1007/s11136-004-4782-z. View

13.

Zhao H, Kanda K . Translation and validation of the standard Chinese version of the EORTC QLQ-C30. Qual Life Res. 2000; 9(2):129-37. DOI: 10.1023/a:1008981520920. View

14.

Kemmler G, Holzner B, Kopp M, Dunser M, Margreiter R, Greil R . Comparison of two quality-of-life instruments for cancer patients: the functional assessment of cancer therapy-general and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30. J Clin Oncol. 1999; 17(9):2932-40. DOI: 10.1200/JCO.1999.17.9.2932. View

15.

Schuck P . Assessing reproducibility for interval data in health-related quality of life questionnaires: which coefficient should be used?. Qual Life Res. 2004; 13(3):571-86. DOI: 10.1023/B:QURE.0000021318.92272.2a. View

16.

Sprangers M, Groenvold M, Arraras J, Franklin J, Te Velde A, Muller M . The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996; 14(10):2756-68. DOI: 10.1200/JCO.1996.14.10.2756. View

17.

Chie W, Chang K, Huang C, Kuo W . Quality of life of breast cancer patients in Taiwan: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and EORTC QLQ-BR23. Psychooncology. 2003; 12(7):729-35. DOI: 10.1002/pon.727. View

18.

Holzner B, Kemmler G, Sperner-Unterweger B, Kopp M, Dunser M, Margreiter R . Quality of life measurement in oncology--a matter of the assessment instrument?. Eur J Cancer. 2001; 37(18):2349-56. DOI: 10.1016/s0959-8049(01)00307-0. View

19.

Sprangers M, Cull A, Groenvold M, Bjordal K, Blazeby J, Aaronson N . The European Organization for Research and Treatment of Cancer approach to developing questionnaire modules: an update and overview. EORTC Quality of Life Study Group. Qual Life Res. 1998; 7(4):291-300. DOI: 10.1023/a:1024977728719. View

20.

Groenvold M, Klee M, Sprangers M, Aaronson N . Validation of the EORTC QLQ-C30 quality of life questionnaire through combined qualitative and quantitative assessment of patient-observer agreement. J Clin Epidemiol. 1997; 50(4):441-50. DOI: 10.1016/s0895-4356(96)00428-3. View