A New Clade of Hepatitis B Virus Subgenotype F1 from Peru with Unusual Properties

Overview

Journal Virus Genes

Specialties Microbiology
Molecular Biology

Date 2008 Jul 24

PMID 18649130

Citations 8

Authors

Markus von Meltzer

Silvia Vasquez

Jianguang Sun

Ulrike C Wendt

Anja May

Wolfram H Gerlich

Monika Radtke

Stephan Schaefer

Affiliations

Soon will be listed here.

Abstract

There are eight genotypes A-H of hepatitis B virus (HBV). Most genotypes are further divided into subgenotypes. Genotypes and subgenotypes influence the natural course of infection and therapy. We analysed nine sera from HBV carriers from Peru. Using the small hepatitis B surface protein HBs, all samples could be grouped to genotype F. Sequencing of three complete Peruvian genomes showed that HBV from Peru belongs to subgenotype F1. Two of the genomes from HBeAg positive carriers coded surprisingly for a stop codon in the polymerase-ORF leading to a translational stop after 213 and 214 aa, respectively. The third isolate from an HBe Ag positive carrier had three deletions: aa 1-53 and aa 111-142 in preS. In addition nt. 2002-2087 in the HBc-ORF were deleted, leading to an HBc starting at aa 66.

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