Classifying Genotype F of Hepatitis B Virus into F1 and F2 Subtypes

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2006 Jan 19

PMID 16419158

Citations 11

Authors

Hideaki Kato

Kei Fujiwara

Robert G Gish

Hiroshi Sakugawa

Hiroshi Yoshizawa

Fuminaka Sugauchi

Etsuro Orito

Ryuzo Ueda

Yasuhito Tanaka

Takanobu Kato

Yuzo Miyakawa

Masashi Mizokami

Affiliations

Soon will be listed here.

Abstract

Aim: To explore the propriety of providing hepatitis B virus (HBV) genotypes F and H with two distinct genotypes.

Methods: Eleven HBV isolates of genotype F (HBV/F) were recovered from patients living in San Francisco, Japan, Panama, and Venezuela, and their full-length sequences were determined. Phylogenetic analysis was carried out among them along with HBV isolates previously reported.

Results: Seven of them clustered with reported HBV/F isolates in the phylogenetic tree constructed on the entire genomic sequence. The remaining four flocked on another branch along with three HBV isolates formerly reported as genotype H. These seven HBV isolates, including the four in this study and the three reported, had a sequence divergence of 7.3-9.5% from the other HBV/F isolates, and differed by > 13.7% from HBV isolates of the other six genotypes (A-E and G). Based on a marked genomic divergence, falling just short of > 8% separating the seven genotypes, these seven HBV/F isolates were classified into F2 subtype and the former seven into F1 subtype provisionally. In a pairwise comparison of the S-gene sequences among the 7 HBV/F2 isolates and against 47 HBV/F1 isolates as well as 136 representing the other six genotypes (A-E and G), two clusters separated by distinct genetic distances emerged.

Conclusion: Based on these analyses, classifying HBV/F isolates into two subtypes (F1 and F2) would be more appropriate than providing them with two distinct genotypes (F and H).

Citing Articles

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Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures.

Demarchi L, Bandeira L, Taira D, Zardin M, Ibanhes M, Esposito A Viruses. 2022; 14(5).

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High diversity of hepatitis B virus genotypes in Panamanian blood donors: a molecular analysis of new variants.

Martinez A, Zaldivar Y, de Castillo Z, Ortiz A, Mendoza Y, Cristina J PLoS One. 2014; 9(8):e103545.

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Hepatitis B virus infection in Latin America: a genomic medicine approach.

Roman S, Jose-Abrego A, Fierro N, Escobedo-Melendez G, Ojeda-Granados C, Martinez-Lopez E World J Gastroenterol. 2014; 20(23):7181-96.

PMID: 24966588 PMC: 4064063. DOI: 10.3748/wjg.v20.i23.7181.

Emergence of hepatitis B virus genotype f in aligarh region of north India.

Sami H, Rizvi M, Azam M, Mukherjee R, Shukla I, Ajmal M Adv Virol. 2014; 2013:846849.

PMID: 24381592 PMC: 3870090. DOI: 10.1155/2013/846849.

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