Osteopenia and Osteoporosis in Adult Baboons (Papio Hamadryas)

Overview

Journal J Med Primatol

Publisher Wiley

Date 2008 Jul 22

PMID 18642436

Citations 14

Authors

L M Havill

S M Levine

D E Newman

M C Mahaney

Affiliations

Soon will be listed here.

Abstract

Background: Little is known about the degree to which baboons, an important animal model in skeletal research, spontaneously experience age-related osteopenia and osteoporosis.

Methods: We measured bone mineral density (BMD) in 667 baboons, assigned T-scores to older animals based on sex-specific young adult reference groups, and compared reproductive history in older females with low BMD to those with normal BMD.

Results: Approximately 25% of older baboon females were osteopenic. No females or males were osteoporotic. Neither parity nor interbirth interval spine clearly distinguished low vs. normal BMD groups. Intersite correspondence in low BMD was highest between sites in the same region rather than sites of the same bone type.

Conclusion: As with humans, osteopenia is common among older females. The absence of osteoporotic animals may be due to colony maintenance resulting in truncation of the aged population and selection for healthier animals in the oldest ranges.

Citing Articles

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Circulating miRNAs associated with bone mineral density in healthy adult baboons.

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Maintenance of bone mass despite estrogen depletion in female common marmoset monkeys (Callithrix jacchus).

Saltzman W, Abbott D, Binkley N, Colman R Am J Primatol. 2018; 81(2):e22905.

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Horticultural activity predicts later localized limb status in a contemporary pre-industrial population.

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Contributions of Nonhuman Primates to Research on Aging.

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