Pancreas Transplantation

Overview

Journal Ann R Coll Surg Engl

Specialty General Surgery

Date 2008 Jul 19

PMID 18634727

Citations 1

Authors

S A White

D W Manas

Affiliations

Soon will be listed here.

Abstract

Over the last 5 years, there has been a resumed interest in treating diabetes by transplantation, particularly islet transplantation. However, despite advances being reported in Canada and the US, replication in the UK has been much more difficult. At present there is still only one treatment that can consistently reverse insulin independence in the long-term and that is whole pancreas transplantation. Long-term normoglycaemia has beneficial effects on preventing and ameliorating the secondary complications of diabetes and will be discussed.

Citing Articles

Present and future cell therapies for pancreatic beta cell replenishment.

Dominguez-Bendala J, Ricordi C World J Gastroenterol. 2013; 18(47):6876-84.

PMID: 23322984 PMC: 3531670. DOI: 10.3748/wjg.v18.i47.6876.

References

Farney A, Cho E, Schweitzer E, Dunkin B, Philosophe B, COLONNA J . Simultaneous cadaver pancreas living-donor kidney transplantation: a new approach for the type 1 diabetic uremic patient. Ann Surg. 2000; 232(5):696-703. PMC: 1421224. DOI: 10.1097/00000658-200011000-00012. View

Tyden G, Bolinder J, Solders G, Brattstrom C, Tibell A, Groth C . Improved survival in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy 10 years after combined pancreas and kidney transplantation. Transplantation. 1999; 67(5):645-8. DOI: 10.1097/00007890-199903150-00001. View

Kennedy W, Navarro X, Goetz F, Sutherland D, Najarian J . Effects of pancreatic transplantation on diabetic neuropathy. N Engl J Med. 1990; 322(15):1031-7. DOI: 10.1056/NEJM199004123221503. View

Ojo A, Meier-Kriesche H, Hanson J, Leichtman A, Magee J, Cibrik D . The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. Transplantation. 2001; 71(1):82-90. DOI: 10.1097/00007890-200101150-00014. View

Fioretto P, Steffes M, Sutherland D, Goetz F, Mauer M . Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med. 1998; 339(2):69-75. DOI: 10.1056/NEJM199807093390202. View

Gruessner R, Sutherland D, Gruessner A . Mortality assessment for pancreas transplants. Am J Transplant. 2004; 4(12):2018-26. DOI: 10.1111/j.1600-6143.2004.00667.x. View

Hering B, Kandaswamy R, Ansite J, Eckman P, Nakano M, Sawada T . Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA. 2005; 293(7):830-5. DOI: 10.1001/jama.293.7.830. View

Larson T, Bohorquez H, Rea D, Nyberg S, Prieto M, Sterioff S . Pancreas-after-kidney transplantation: an increasingly attractive alternative to simultaneous pancreas-kidney transplantation. Transplantation. 2004; 77(6):838-43. DOI: 10.1097/01.tp.0000114611.73689.3b. View

Reddy K, Stablein D, Taranto S, Stratta R, Johnston T, Waid T . Long-term survival following simultaneous kidney-pancreas transplantation versus kidney transplantation alone in patients with type 1 diabetes mellitus and renal failure. Am J Kidney Dis. 2003; 41(2):464-70. DOI: 10.1053/ajkd.2003.50057. View

10.

Wang Q, Klein R, Moss S, Klein B, Hoyer C, Burke K . The influence of combined kidney-pancreas transplantation on the progression of diabetic retinopathy. A case series. Ophthalmology. 1994; 101(6):1071-6. DOI: 10.1016/s0161-6420(94)31216-4. View

11.

Koznarova R, Saudek F, Sosna T, Adamec M, Jedinakova T, Boucek P . Beneficial effect of pancreas and kidney transplantation on advanced diabetic retinopathy. Cell Transplant. 2001; 9(6):903-8. DOI: 10.1177/096368970000900617. View

12.

Jukema J, Smets Y, van der Pijl J, Zwinderman A, Vliegen H, Ringers J . Impact of simultaneous pancreas and kidney transplantation on progression of coronary atherosclerosis in patients with end-stage renal failure due to type 1 diabetes. Diabetes Care. 2002; 25(5):906-11. DOI: 10.2337/diacare.25.5.906. View

13.

Gruessner A, Sutherland D . Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004. Clin Transplant. 2005; 19(4):433-55. DOI: 10.1111/j.1399-0012.2005.00378.x. View

14.

Ryan E, Paty B, Senior P, Bigam D, Alfadhli E, Kneteman N . Five-year follow-up after clinical islet transplantation. Diabetes. 2005; 54(7):2060-9. DOI: 10.2337/diabetes.54.7.2060. View

15.

Pruijm M, de Fijter H, Doxiadis I, Vandenbroucke J . Preemptive versus Non-preemptive simultaneous pancreas-kidney transplantation: a single-center, long-term, follow-up study. Transplantation. 2006; 81(8):1119-24. DOI: 10.1097/01.tp.0000208574.48230.fd. View

16.

Humar A, Ramcharan T, Kandaswamy R, Matas A, Gruessner R, Gruessner A . Pancreas after kidney transplants. Am J Surg. 2001; 182(2):155-61. DOI: 10.1016/s0002-9610(01)00676-6. View

17.

Froud T, Ricordi C, Baidal D, Hafiz M, Ponte G, Cure P . Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant. 2005; 5(8):2037-46. DOI: 10.1111/j.1600-6143.2005.00957.x. View

18.

Smets Y, Westendorp R, van der Pijl J, de Charro F, Ringers J, de Fijter J . Effect of simultaneous pancreas-kidney transplantation on mortality of patients with type-1 diabetes mellitus and end-stage renal failure. Lancet. 1999; 353(9168):1915-9. DOI: 10.1016/S0140-6736(98)07513-8. View

19.

Fioretto P, Sutherland D, Najafian B, Mauer M . Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients. Kidney Int. 2006; 69(5):907-12. DOI: 10.1038/sj.ki.5000153. View

20.

Venstrom J, McBride M, Rother K, Hirshberg B, Orchard T, Harlan D . Survival after pancreas transplantation in patients with diabetes and preserved kidney function. JAMA. 2003; 290(21):2817-23. DOI: 10.1001/jama.290.21.2817. View