Non-protein Coding RNA Biomarkers and Differential Expression in Cancers: a Review

Overview

Journal J Exp Clin Cancer Res

Publisher Biomed Central

Specialty Oncology

Date 2008 Jul 18

PMID 18631387

Citations 33

Authors

Massimo Mallardo

Palmiro Poltronieri

Oscar Fernando DUrso

Affiliations

Soon will be listed here.

Abstract

Background: In these years a huge number of human transcripts has been found that do not code for proteins, named non-protein coding RNAs. In most cases, small (miRNAs, snoRNAs) and long RNAs (antisense RNA, dsRNA, and long RNA species) have many roles, functioning as regulators of other mRNAs, at transcriptional and post-transcriptional level, and controlling protein ubiquitination and degradation. Various species of npcRNAs have been found differentially expressed in different types of cancer. This review discusses the published data and new results on the expression of a subset of npcRNAs.

Conclusion: These results underscore the complexity of the RNA world and provide further evidence on the involvement of functional RNAs in cancer cell growth control.

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